| Work | Description | Characters |
|---|---|---|
| Nepenthe | 7th Episode of Star Trek: Picard | 3 |
| Never Go Back | Novel by Lee Child | 1 |
| Never Say Never Again | 1983 James Bond film directed by Irvin Kershner | 1 |
| New Game! | Japanese manga series | 1 |
| New Game! | Japanese anime television series | 1 |
| New Girl | American sitcom | 4 |
| New Hell Girl | Japanese manga series | 1 |
| New Mutants | 1983 comic book series | 1 |
| New Super Luigi U | 2013 platform game | 2 |
| New Super Mario Bros. | side-scrolling platform video game developed by Nintendo for the Nintendo DS in 2006 | 1 |
| New Super Mario Bros. 2 | 2012 side-scroller platform video game developed by Nintendo | 1 |
| New Super Mario Bros. U | 2012 platform video game | 1 |
| New Super Mario Bros. U Deluxe | 2019 video game for Nintendo Switch | 1 |
| New Testament | second division of the Christian biblical canon | 2 |
| Nickelodeon All-Star Brawl | 2021 video game developed by Fair Play Labs and Ludosity | 1 |
| Nicktoons: Attack of the Toybots | 2007 video game | 1 |
| Nicktoons: Freeze Frame Frenzy | 2004 video game | 1 |
| Nicktoons Unite! | 2005 video game | 1 |
| NieA_7 | Japanese anime television series | 1 |
| Nier | 2010 video game | 6 |
| NieR: Automata | 2017 action role-playing video game | 9 |
| Nightcrawler | 2014 film | 1 |
| Night School | 2016 novel by Lee Child | 1 |
| Nightshade | Book by Laurell K. Hamilton, from 1992 | 5 |
| Nigrinus | work by Lucian | 1 |
| Nihon Shoki | 8th century book of classical Japanese history | 1 |
| Nineteen Eighty-Four | dystopian novel written by George Orwell | 2 |
| Ninja Turtles: The Next Mutation | American 1997–1998 live-action television series | 1 |
| Nisekoi | Japanese anime television series | 2 |
| Nisekoi | Japanese manga series | 2 |
| Nixon in China | opera by John Adams | 1 |
| Noblesse | Japanese anime television series | 1 |
| Nobody Knows the Tribbles I've Seen | comic | 8 |
| Nobunaga Concerto | Japanese manga series, television anime, a live-action television series, and a live-action film | 1 |
| No Country for Old Men | 2007 film directed by Ethan and Joel Coen | 3 |
| No Country for Old Men | novel by Cormac McCarthy | 1 |
| No Game No Life | 2014 anime series | 2 |
| No Good Deed | 2017 film by David Leitch | 1 |
| No Matter How I Look at It, It's You Guys' Fault I'm Not Popular! | Japanese manga series | 1 |
| No Matter How I Look at It, It's You Guys' Fault I'm Not Popular! | Japanese anime television series | 1 |
| No! No! A Thousand Times No!! | 1935 film by Dave Fleischer | 1 |
| Noragami | Japanese anime television series | 2 |
| Noragami | Japanese manga series by Adachitoka | 2 |
| Norse mythology | body of mythology of the North Germanic people stemming from Norse paganism and continuing after the Christianization of Scandinavia and into the Scandinavian folklore of the modern period | 1 |
| …Nor the Battle to the Strong | episode of Star Trek: Deep Space Nine (S5 E4) | 9 |
| Northern Lights | 1995 novel by Philip Pullman | 2 |
| North Star | episode of Star Trek: Enterprise (S3 E9) | 4 |
| Nosferatu | 1922 film directed by F. W. Murnau | 1 |
| Nosferatu | 2024 film directed by Robert Eggers | 1 |
| Notes from Underground | 1864 novella by Fyodor Dostoyevsky | 1 |
| Nothing to Lose | twelfth book in the Jack Reacher series by Lee Child | 1 |
| No Time to Die | James Bond film by Cary Joji Fukunaga scheduled for 2021 | 1 |
| Not Now | 1936 film by Dave Fleischer | 1 |
| Numbers | fourth book of the Bible | 3 |
| Nyan Koi! | Japanese anime television series | 1 |
| Nyan Koi! | Japanese manga series | 1 |
| Obi-Wan Kenobi | American streaming television series | 2 |
| Objective: Bajor | Book by John Peel, from 1996 | 8 |
| Objects in Space | episode of Firefly (S1 E14) | 2 |
| Occupe-toi d'Amélie! | play written by Georges Feydeau | 1 |
| Ocean's 11 | 1960 heist film directed by Lewis Milestone | 1 |
| Ocean's Eleven | 2001 film by Steven Soderbergh | 1 |
| Ocean's Thirteen | 2007 film by Steven Soderbergh | 1 |
| Ocean's Twelve | 2004 film directed by Steven Soderbergh | 1 |
| Octopath Traveler | 2018 role-playing video game | 4 |
| Octopussy | 1983 film by John Glen | 1 |
| Odyssey | epic poem attributed to Homer | 8 |
| Oedipus Rex | ancient Greek tragedy by Sophocles | 2 |
| Oh My Goddess! | Japanese manga series | 2 |
| Oh My Goddess! | Japanese anime television series | 2 |
| Olaf's Frozen Adventure | 2017 animated short film | 3 |
| Old Santeclaus with Much Delight | anonymous 1821 Christmas poem | 1 |
| Old Wounds | Book by Christie Golden, from 2004 | 14 |
| Ol' Man Adam an' His Chillun | collection of folk tales | 1 |
| Omashu | episode of Avatar: The Last Airbender (S1 E3) | 1 |
| Omoi, Omoware, Furi, Furare | Japanese manga | 1 |
| Omori | 2020 horror role-playing video game | 1 |
| Once Burned | Book by Peter David, from 1998 | 3 |
| Once Upon a Planet | Short story | 6 |
| Once Upon a Time | American television series | 2 |
| Once Upon a Time in Hollywood | 2019 film directed by Quentin Tarantino | 1 |
| Once Upon a Time in Hollywood | 2021 novel by Quentin Tarantino | 1 |
| Once Upon a Time... Man | French animated TV series | 2 |
| One Flew Over the Cuckoo's Nest | novel by Ken Kesey | 1 |
| One Flew Over the Cuckoo's Nest | 1975 drama film based on the novel by Ken Kesey | 1 |
| One Foot in the Grave | British TV Comedy Series | 1 |
| One Hundred and One Dalmatians | 1961 American animated adventure film produced by Walt Disney | 1 |
| One Piece | Japanese manga series | 11 |
| One Piece | Japanese media franchise | 26 |
| One Piece | Japanese anime television series | 23 |
| One Piece: Stampede | 2019 Japanese anime film | 1 |
| One-Punch Man | Japanese anime television series | 2 |
| One-Punch Man | Japanese manga series by One | 1 |
| One-Punch Man | media franchise | 19 |
| One-Punch Man | Japanese manga series by Yūsuke Murata | 2 |
| One Shot | book by Lee Child | 1 |
| One Thousand and One Nights | collection of west asian stories and folk tales compiled in Arabic | 2 |
| One, Two, Buckle My Shoe | book | 1 |
| On Her Majesty's Secret Service | 1969 James Bond film by Peter R. Hunt | 1 |
| Only Fools and Horses | British television sitcom | 1 |