| Work | Description | Characters |
|---|---|---|
| The Death of Superman | 2018 film directed by Sam Liu | 2 |
| The Decameron | 14th-century medieval allegory by Giovanni Boccaccio | 1 |
| The Defenders | 2017 TV series by Netflix, based on Marvel's comic books | 1 |
| The Devil and Tom Walker | short story by Washington Irving | 1 |
| The Devil Is a Part-Timer! | Japanese light novel series | 1 |
| The Devil Is a Part-Timer! | Japanese manga series | 1 |
| The Devil Is a Part-Timer! | Japanese anime television series | 1 |
| The Devil's Heart | Book by Carmen Carter | 6 |
| The Devil Wears Prada | 2006 comedy-drama film directed by David Frankel | 5 |
| The Devil Wears Prada | 2003 novel by Lauren Weisberger | 3 |
| The Die is Cast | episode of Star Trek: Deep Space Nine (S3 E21) | 4 |
| The Disappearance of Haruhi Suzumiya | 2010 Japanese anime film | 3 |
| The Disappearance of Lady Frances Carfax | short story by Arthur Conan Doyle | 1 |
| The Disastrous Life of Saiki K. | Japanese manga series | 3 |
| The Disastrous Life of Saiki K. | anime series | 3 |
| The Disinherited | novel by Peter David, Michael Jan Friedman, and Robert Greenberger | 5 |
| The Dispossessed | 1974 novel by Ursula K. Le Guin | 1 |
| The Divine Comedy | epic poem by Dante Alighieri | 18 |
| The Dominion: Olympus Descending | Book by David R. George III | 14 |
| The Door | episode of Game of Thrones (S6 E5) | 1 |
| The Dragon Prince | television series | 1 |
| The Dreamer and the Dream | Star Trek short story | 1 |
| The Dreaming City | book by Michael Moorcock | 1 |
| The Edge of Seventeen | 2016 film directed by Kelly Fremon Craig | 1 |
| The Edge of the World | short story by Andrzej Sapkowski | 1 |
| The Elder Scrolls: Legends | video game | 3 |
| The Elder Scrolls V: Skyrim | 2011 open world action role-playing video game | 3 |
| The Elder Scrolls V: Skyrim VR | 2018 video game | 1 |
| The Embodiment of Scarlet Devil | bullet hell / danmaku video game | 3 |
| The Emerald City of Oz | novel by L. Frank Baum | 1 |
| The Eminence in Shadow | Japanese light novel series | 1 |
| The Eminence in Shadow | Japanese anime television series | 1 |
| The Eminence in Shadow | Japanese manga series | 1 |
| The Empath | episode of Star Trek: The Original Series (S3 E12) | 5 |
| The Emperor's New Groove | 2000 animated Disney film by Mark Dindal | 1 |
| The Emperor's New School | television series | 1 |
| The End is the Beginning | 3rd Episode of Star Trek: Picard | 1 |
| The End of Evangelion | 1997 film directed by Hideaki Anno | 1 |
| The End of the F***ing World | 2017 British comedy-drama television series | 3 |
| The Enemy | novel by Lee Child | 1 |
| The Enemy Within | 1966 episode of Star Trek: The Original Series (S1 E5) directed by Leo Penn | 6 |
| The Engineer's Thumb | 1923 film by George Ridgwell | 1 |
| The Enola Holmes Mysteries | young adult fiction series by Nancy Springer | 1 |
| The Entropy Effect | novel by Vonda McIntyre | 4 |
| The Equalizer | 2014 film directed by Antoine Fuqua | 1 |
| The Equalizer 2 | 2018 film directed by Antoine Fuqua | 1 |
| The Equalizer 3 | upcoming American action film | 1 |
| The Escape | Book by Dean Wesley Smith and Kristine Kathryn Rusch, from 1995 | 6 |
| The Expanse | book | 3 |
| The Expanse | series of space opera novels by James S. A. Corey | 1 |
| The Expanse | American science fiction television series | 1 |
| The Exploits of Moominpappa | the fourth book in the Moomin series by Tove Jansson | 1 |
| The Eye of the Beholder | novel | 6 |
| The Eyes of the Beholders | Book | 6 |
| The Fabulous Baron Munchausen | 1962 film by Karel Zeman | 1 |
| The Falcon and the Winter Soldier | American streaming television miniseries | 2 |
| The Familiar of Zero | Japanese anime television series | 1 |
| The Familiar of Zero | Japanese light novel series | 2 |
| The Family Corleone | novel by Edward Falco | 3 |
| The Fantastic Four | unreleased superhero film completed in 1994 directed by Oley Sassone | 1 |
| The Fantastic Four: First Steps | 2025 film directed by Matt Shakman | 1 |
| The Far Cry Experience | 2012 promotional web series | 1 |
| The Farther Shore | book by Christie Golden | 10 |
| The Fast and the Furious | 2001 film directed by Rob Cohen | 1 |
| The Fate of the Furious | 2017 film directed by F. Gary Gray | 1 |
| The Fate Of The Phoenix | Book by Sondra Marshak and Myrna Culbreath, from 1979 | 5 |
| The Fearful Summons | Book by Denny Martin Flinn | 5 |
| The Fellowship of the Ring | 1954 book by J. R. R. Tolkien | 6 |
| The Fifth Element | 1997 science fiction film by Luc Besson | 1 |
| The Final Fury | Book by Dafydd ab Hugh, from 1996 | 6 |
| The Final Nexus | book by Gene DeWeese | 5 |
| The Final Problem | short story by Sir Arthur Conan Doyle | 1 |
| The Final Reflection | book by John M. Ford | 4 |
| The Finding of Moses | poem | 1 |
| The Fire and the Rose | Book by David R. George III | 2 |
| The Flash | 2014 TV series | 7 |
| The Flash | comic book series | 2 |
| The Flash | 1990 American television series | 1 |
| The Flowers of Evil | 2009 Japanese manga series | 3 |
| The Forbidden Kingdom | 2008 film by Rob Minkoff | 1 |
| The Forsaken | episode of Star Trek: Deep Space Nine (S1 E17) | 3 |
| The Fortress of the Pearl | book by Michael Moorcock | 1 |
| The Fox and the Hound | 1981 American animated film | 1 |
| The Foxy Hunter | 1937 film by Dave Fleischer | 1 |
| The Fresh Prince of Bel-Air | television series | 1 |
| The Galactic Whirlpool | Book by David Gerrold, from 1980 | 5 |
| The Galileo Seven | episode of Star Trek: The Original Series (S1 E16) | 6 |
| The Garden | Book by Melissa Scott, from 1997 | 6 |
| The Garfield Show | French animated television series | 1 |
| The Girl from U.N.C.L.E. | television series | 1 |
| The Girl in the Spider's Web | novel by David Lagercrantz | 2 |
| The Girl Who Kicked the Hornets' Nest | 2007 Book by Stieg Larsson | 2 |
| The Girl Who Leapt Through Time | 2006 anime film directed by Mamoru Hosoda | 2 |
| The Girl Who Played with Fire | 2006 Book by Stieg Larsson | 2 |
| The Girl Who Takes an Eye for an Eye | fifth novel in the posthumously-published Millennium series of crime novels by Stieg Larsson | 2 |
| The Girl with the Dragon Tattoo | 2005 book by Stieg Larsson | 2 |
| The Godfather | 1969 novel by Mario Puzo | 7 |
| The Godfather | 2006 open world action-adventure video game | 3 |
| The Godfather | 1972 American film directed by Francis Ford Coppola | 1 |
| The Godfather II | 2009 video game | 3 |