| Work | Description | Characters |
|---|---|---|
| The Rocky Horror Picture Show | 1975 film by Jim Sharman | 1 |
| The Rocky Horror Show | musical | 1 |
| The Rolling Girls | Japanese anime television series | 1 |
| The Rolling Girls | Japanese manga series | 1 |
| The Romulan Prize | Book by Simon Hawke | 6 |
| The Romulan Stratagem | Book by Robert Greenberger | 7 |
| The Romulan Way | book by Diane Duane | 1 |
| The Root of All Rage | Book by Bernd Perplies and Christian Humberg | 5 |
| The Royal Scandal | 2003 film directed by Rodney Gibbons | 1 |
| The Rules of Attraction | 1987 novel by Bret Easton Ellis | 1 |
| The Sailor on the Seas of Fate | book by Michael Moorcock | 1 |
| The Sandman | Netflix's future television adaptation of Neil Gaiman's "The Sandman" | 2 |
| The Sandman | comic series by Neil Gaiman | 3 |
| The Sarah Jane Adventures | British science fiction television programme | 1 |
| The Saxon Stories | 2004-2018 series of eleven books by Bernard Cornwell | 2 |
| The Scared Crows | 1939 film by Dave Fleischer | 1 |
| The Sea of Fertility | cycle of four novels by the Japanese author Yukio Mishima | 3 |
| The Search | book | 6 |
| The Search | Mission in Star Trek: Online | 1 |
| The Searchers | 1956 film by John Ford | 1 |
| The Search for Spock | book by Vonda N. McIntyre | 4 |
| The Search: Part 1 | episode of Star Trek: Deep Space Nine (S3 E1) | 6 |
| The Search: Part 2 | episode of Star Trek: Deep Space Nine (S3 E2) | 6 |
| These Are the Voyages… | episode of Star Trek: Enterprise (S4 E22) | 2 |
| The Second Jungle Book | book | 1 |
| The Secret Diary of Laura Palmer | novel by Jennifer Lynch | 1 |
| The Secret Life of Bees | 2008 film directed by Gina Prince-Bythewood | 1 |
| The Secret Life of Bees | book by Sue Monk Kidd | 1 |
| The Secret Life of Pets | 2016 American 3D computer animated comedy film | 1 |
| The Secret Life of Walter Mitty | 1939 short story by James Thurber | 1 |
| The Secret of the Sword | 1985 US animated film directed by Bill Reed and Gwen Wetzler | 1 |
| The Secret Pilgrim | book | 1 |
| The Seven Deadly Sins | Japanese anime television series | 1 |
| The Seven Deadly Sins | Japanese manga series | 1 |
| The Shannara Chronicles | American fantasy drama television series | 1 |
| The Shanty Where Santy Claus Lives | 1933 film | 1 |
| The Shawshank Redemption | 1994 film directed by Frank Darabont | 1 |
| The Shield | American drama television series | 1 |
| The Shining | novel by Stephen King | 1 |
| The Shining | 1980 British-American horror film by Stanley Kubrick | 1 |
| The Shining | 1997 American television miniseries | 1 |
| The Siege | Book by Peter David, from 1993 | 7 |
| The Siege | episode of Star Trek: Deep Space Nine (S2 E3) | 1 |
| The Sign of the Four | novel | 2 |
| The Silence of the Lambs | 1991 thriller movie directed by Jonathan Demme | 2 |
| The Silence of the Lambs | 1988 book by Thomas Harris | 2 |
| The Silmarillion | collection of J. R. R. Tolkien's mythopoeic works | 8 |
| The Silver Chair | children's fantasy novel by C. S. Lewis, 1953 | 2 |
| The Simpsons | American animated sitcom created by Matt Groening for the Fox Broadcasting Company | 28 |
| The Simpsons Movie | 2007 film directed by David Silverman | 1 |
| The Slaver Weapon | Short story | 6 |
| The Sleeping Sorceress | book by Michael Moorcock | 1 |
| The Slime Diaries: That Time I Got Reincarnated as a Slime | Japanese manga series | 1 |
| The Slime Diaries: That Time I Got Reincarnated as a Slime | Japanese anime television series | 1 |
| The Smurfs | 1981 animated television series | 1 |
| The Smurfs | Belgian comic and television franchise | 1 |
| The Snow Maiden | play by Alexander Ostrovsky | 1 |
| The Snow Maiden | opera by Nikolaj Rimski-Korsakov | 1 |
| The Soldiers of Fear | Book by Dean Wesley Smith and Kristine Kathryn Rusch, from 1996 | 6 |
| The Song of Saya | video game | 8 |
| The Son of Dr. Jekyll | 1951 American film by Seymour Friedman | 2 |
| The Sopranos | American television series | 16 |
| The Sorcerer's Apprentice | 1940 segment from Disney's Fantasia directed by James Algar | 1 |
| The sorrows of young Werther | novel by Johann Wolfgang von Goethe | 1 |
| The Soul Key | Book by Olivia Woods | 11 |
| The Sound and the Fury | novel by William Faulkner | 2 |
| The Southern Vampire Mysteries | book series | 5 |
| The Spectacular Spider-Man | 2008 American animated television series | 1 |
| The SpongeBob Movie: Sponge on the Run | 2020 American 3D animated/live action comedy film directed by Tim Hill | 4 |
| The SpongeBob Movie: Sponge Out of Water | 2015 American 3D animated/live action comedy film directed by Paul Tibbitt | 6 |
| The SpongeBob Musical | musical | 1 |
| The SpongeBob SquarePants Movie | 2004 American animated comedy film directed by Stephen Hillenburg | 8 |
| The Spy Who Came in from the Cold | 1963 novel by John le Carré | 1 |
| The Spy Who Loved Me | 1977 James Bond film by Lewis Gilbert | 1 |
| The Starless World | book by Gordon Eklund | 5 |
| The Starship Trap | book by Mel Gilden | 5 |
| The Star Trek Bartender's Guide and Punch Book | book | 1 |
| The Star Trek Book | written work | 9 |
| The Star Wars Holiday Special | 1978 American television special | 1 |
| The Stranger | 1942 novel by Albert Camus | 1 |
| The String of Pearls | serial novel by James Malcolm Rymer | 1 |
| The Subtle Knife | 1997 novel by Philip Pullman | 2 |
| The Super Hero Squad Show | American animated television series | 7 |
| The Superman/Aquaman Hour of Adventure | television series | 2 |
| The Super Mario Bros. Super Show! | 1989 American animated TV series | 4 |
| The Super Powers Team: Galactic Guardians | television series | 2 |
| The Suppliants | ancient Greek tragedy by Euripides | 2 |
| The Survivor | Short story | 6 |
| The Swing School | 1938 film by Dave Fleischer | 1 |
| The Sword in the Stone | American animated fantasy comedy film produced by Walt Disney | 1 |
| The Sword of Kahless | episode of Star Trek: Deep Space Nine (S4 E9) | 6 |
| The Sword of Truth | series of twelve epic fantasy novels written by Terry Goodkind | 1 |
| The Tables of the Law | novel by Thomas Mann | 1 |
| The Talented Mr. Ripley | 1999 film by Anthony Minghella | 1 |
| The Talented Mr. Ripley | novel by Patricia Highsmith | 1 |
| The Tales of Wukong | 2017 film by Derek Kwok | 1 |
| The Tears of the Singers | book by Melinda M. Snodgrass | 4 |
| The Tempest | play by William Shakespeare | 1 |
| The Ten Commandments | 2007 film by Bill Boyce and John Stronach | 1 |
| The Ten Commandments | 1956 American film directed by Cecil B. DeMille | 1 |