| Work | Description | Characters |
|---|---|---|
| Troy | 2004 film by Wolfgang Petersen | 1 |
| True Blood | American television drama series | 7 |
| True Detective | American television series | 4 |
| True Detective, season 1 | season of television series | 1 |
| True Tears | Japanese anime television series | 1 |
| Tsubasa: Reservoir Chronicle | 2005 Japanese manga by Clamp | 3 |
| Tsubasa: Reservoir Chronicle | 2005 Japanese anime by Clamp | 1 |
| Tunnel Trough the Stars | Book by John Vornholt, from 1998 | 5 |
| Turtles Forever | 2009 American science fiction martial arts animated film | 1 |
| 'Twas the Night | 2001 movie directed by Nick Castle | 1 |
| Twenty Thousand Leagues Under the Sea | novel by Jules Verne | 1 |
| Twice Upon a Time | special episode of Doctor Who | 1 |
| Twilight | Star Trek novel by David R. George III, from 2002 | 18 |
| Twilight | series of vampire romance novels by Stephenie Meyer | 4 |
| Twilight's End | Book by Jerry Oltion, from 2000 | 5 |
| Twin Peaks | 1990's American drama television series | 3 |
| Twin Peaks | 2017 TV series | 2 |
| Twin Peaks: Fire Walk with Me | 1992 film by David Lynch | 2 |
| Two and a Half Men | TV series (2003-2015) | 5 |
| Uhura's Song | Science fiction novel | 4 |
| Ultimate Marvel vs. Capcom 3 | fighting video game | 9 |
| Ultimate Otaku Teacher | Japanese manga series | 1 |
| Ultimate Otaku Teacher | Japanese anime television series | 1 |
| Ultimate Spider-Man | 2005 video game | 1 |
| Ultimate Spider-Man | American superhero animated series | 3 |
| Ultra Street Fighter IV | 2014 video game | 1 |
| Ulysses | novel by the Irish author James Joyce | 4 |
| Umineko no Naku Koro ni | episodic video game | 1 |
| Umineko no Naku Koro ni Chiru | episodic video game | 1 |
| Umineko When They Cry | Japanese anime television series | 1 |
| Uncanny X-Men | comic book series | 14 |
| Uncharted 2: Among Thieves | 2009 video game | 1 |
| Uncharted 3: Drake's Deception | 2011 action-adventure third-person shooter platform video game | 1 |
| Uncharted 4: A Thief's End | 2016 video game | 1 |
| Uncharted: Drake's Fortune | 2007 video game published by Sony | 1 |
| Uncharted: Golden Abyss | video game | 1 |
| Uncharted: The Fourth Labyrinth | 1 | |
| Unconnected Marketeers | 2021 video game | 1 |
| Undead Nightmare | 2010 video game downloadable content | 1 |
| Undefined Fantastic Object | 2009 video game | 1 |
| Undertale | 2015 role-playing video game | 15 |
| Unfinished Tales | book | 2 |
| Unidentified Flying Oddball | 1979 film by Russ Mayberry | 3 |
| Unification | Book by Jeri Taylor, from 1991 | 6 |
| Unification III | episode of television series Star Trek: Discovery | 2 |
| Unity | Star Trek novel by S. D. Perry, from 2003 | 18 |
| Untitled third Fantastic Beasts film | 2022 film directed by David Yates | 2 |
| Unworthy | Book by Kirsten Beyer, from 2009 | 8 |
| Up | 2009 American 3D computer-animated comedy-adventure film | 2 |
| Up on the House Top | 1864 Christmas song by Benjamin Hanby | 1 |
| Ushio and Tora | manga | 1 |
| Vaas: Insanity | Far Cry DLC | 1 |
| Valhalla | Book by Nathan Archer, from 1995 | 5 |
| Valorant | 2020 free-to-play multiplayer first-person shooter video game developed by Riot Games | 12 |
| Vampire Hunter D | novel series by Hideyuki Kikuchi | 2 |
| Van Helsing | 2004 American period action horror film | 1 |
| Van Helsing: The London Assignment | 2004 animated short film | 1 |
| Vectors | Book by Dean Wesley Smith and Kristine Kathryn Rusch | 16 |
| Veep | 2012–2019 American comedy television series | 4 |
| Vendetta | Star Trek: The Next Generation tie-in novel | 7 |
| Venom | 2018 film by Ruben Fleischer | 1 |
| Veritas | episode of Star Trek: Lower Decks | 2 |
| V for Vendetta | graphic novel by Alan Moore and David Lloyd | 2 |
| V for Vendetta | 2005 British dystopian thriller film directed by James McTeigue | 2 |
| Vikings | Canadian-Irish historical drama television series | 6 |
| Vinland Saga | Japanese manga series | 3 |
| Vinland Saga | Japanese anime television series | 3 |
| Violations | Book by Susan Wright, from 1995 | 6 |
| Violet Detector | 1 | |
| Violet Evergarden | Japanese anime television series | 1 |
| Violet Evergarden | Japanese light novel series | 2 |
| Vixen | animated web series | 1 |
| Vocaloid | singing synthesizer by Yamaha | 1 |
| Vows of the Peacock | early 14th-century chivalric poem by Jacques de Longuyon | 1 |
| Vulcan | 4 | |
| Vulcan! | Star Trek novel | 5 |
| Vulcan's Glory | book by D. C. Fontana | 2 |
| Wallace and Gromit | British clay animation comedy series | 3 |
| Wallander | British television series | 1 |
| Wallander | series of films and miniseries with Rolf Lassgård by Sveriges Television (1994-2006) | 1 |
| Wallander | Swedish TV4 series, 2005–2013 | 1 |
| Wallander novels | 1 | |
| WALL-E | 2008 video game | 1 |
| WALL·E | 2008 American computer-animated romantic science fiction film directed by Andrew Stanton | 1 |
| Wall Street | 1987 film by Oliver Stone | 1 |
| WandaVision | 2021 American streaming television miniseries | 3 |
| Wandering Witch: The Journey of Elaina | Japanese light novel series | 1 |
| Wandering Witch: The Journey of Elaina | Japanese anime television series | 1 |
| Wandering Witch: The Journey of Elaina | Japanese manga series | 1 |
| Warchild | Book by Esther Friesner, from 1994 | 5 |
| Warcraft | video game series | 1 |
| Warcraft | 2016 film by Duncan Jones | 2 |
| Warcraft Adventures: Lord of the Clans | unreleased video game | 1 |
| Warcraft: Day of the Dragon | book | 3 |
| Warcraft III: Reign of Chaos | 2002 video game | 9 |
| Warcraft III: The Frozen Throne | computer game by Blizzard Entertainment | 8 |
| Warcraft II: Tides of Darkness | fantasy-themed real-time strategy game published by Blizzard Entertainment | 3 |
| Warcraft: Lord of the Clans | book | 1 |
| Warcraft: Of Blood and Honor | book | 1 |
| Warcraft: Orcs & Humans | 1994 video game | 1 |