| Work | Description | Characters |
|---|---|---|
| Dune sequels series | Sequel of Chapterhouse Dune by Brian Herbert and Kevin J. Anderson | 1 |
| Dune series | set of all the Dune series by Frank Herbert, Brian Herbert and Kevin J. Anderson | 1 |
| Durarara!! | 2010 Japanese light novel series written by Ryohgo Narita, with illustrations by Suzuhito Yasuda, and anime series adaptations | 5 |
| Dwellers in the Crucible | book by Margaret Wander Bonanno | 4 |
| Dynasty | 2017 American prime time television soap opera | 1 |
| Dynasty | 1980s American prime time television soap opera | 1 |
| Earthsea | 2004 TV miniseries, loosely based on the Earthsea trilogy directed by Robert Lieberman | 1 |
| EastEnders | British drama season TV soap opera | 2 |
| Ecclesiastes | book of the Bible | 1 |
| Echo | upcoming American superhero television series | 1 |
| Echo Burning | book by Lee Child | 1 |
| Echoes | Book by Dean Wesley Smith, Kristine Kathryn Rusch, and Nina Kiriki Hoffman, from 1998 | 6 |
| Edward Scissorhands | 1990 film | 2 |
| Egyptian mythology | myths of the Ancient Egyptians | 1 |
| Ehrgeiz | fighting game | 4 |
| El Camino: A Breaking Bad Movie | 2019 film directed by Vince Gilligan | 2 |
| Electra | ancient Greek tragedy by Euripides | 1 |
| Elemental | 2023 American animated film directed by Peter Sohn | 5 |
| Elementary, My Dear Turtle | episode of the 1987–1996 Teenage Mutant Ninja Turtles animated television series | 3 |
| Elephants Can Remember | book | 1 |
| Elf | 2003 American comedy film starring Will Ferrell directed by Jon Favreau | 1 |
| Elric of Melniboné | book | 1 |
| Elric saga | series of books by Michael Moorcock | 1 |
| Emissary | book | 8 |
| Emissary, Part I | episode of Star Trek: Deep Space Nine (S1 E1) | 6 |
| Emissary, Part II | episode of Star Trek: Deep Space Nine (S1 E2) | 4 |
| Emma | 1815 novel by Jane Austen | 1 |
| Emma | Japanese manga series | 1 |
| Emma – A Victorian Romance | Japanese anime television series | 1 |
| Encanto | 2021 American computer animated film | 2 |
| Encounter at Farpoint | Book | 7 |
| Endeavour | British television series | 1 |
| Ender in Exile | book by Orson Scott Card | 1 |
| Ender's Game | 1985 book by Orson Scott Card | 2 |
| Ender's Game | 2013 science fiction film directed by Gavin Hood | 1 |
| Ender's Game hexalogy | 1985-2008 Series of six SF novels by Orson Scott Card | 2 |
| Ender's Shadow | 1999 Book by Orson Scott Card | 1 |
| Endgame | episode of The Legend of Korra (S1 E12) | 1 |
| Endgame | book by Diane Carey | 6 |
| Enemy of My Enemy | book | 14 |
| Enemy Unseen | book by V.E. Mitchell | 5 |
| Engaged to the Unidentified | Japanese anime television series | 2 |
| Engaged to the Unidentified | Japanese manga series | 2 |
| Enola Holmes | 2020 film by Harry Bradbeer | 1 |
| Enola Holmes 2 | 2022 film directed by Harry Bradbeer | 1 |
| Enough Rope | 1960 film | 1 |
| Enterprise: The First Adventure | Book by Vonda N. McIntyre, from 1986 | 5 |
| Enter the Matrix | 2003 video game | 3 |
| Envoys | episode of Star Trek: Lower Decks | 1 |
| Epic of Gilgamesh | epic poem from Mesopotamia, is amongst the earliest surviving works of literature | 1 |
| Epistle of James | book of the Bible | 1 |
| Epistle to the Galatians | book of the Bible | 1 |
| Epistle to the Hebrews | book of the Bible | 3 |
| Epistle to the Romans | book of the Bible | 2 |
| Erased | Japanese anime television series | 1 |
| Erased | Japanese manga series | 1 |
| Ergo Proxy | Japanese anime television series | 2 |
| Eternal Fire | short story by Andrzej Sapkowski | 1 |
| Eternal Sunshine of the Spotless Mind | 2004 film directed by Michel Gondry | 1 |
| Et in Arcadia Ego, Part 1 | 9th Episode of Star Trek: Picard | 3 |
| Et in Arcadia Ego, Part 2 | 10th Episode of Star Trek: Picard | 3 |
| Eugene Onegin | novel in verse by Alexander Pushkin | 1 |
| Euphoria | 2019 American teen drama television series | 12 |
| Eureka | American science fiction television series that premiered on Syfy on July 18, 2006 | 3 |
| Eureka Seven | 2005 anime series | 2 |
| Euskal Herriaren historia nafarra | Basque comic book | 1 |
| Evangelion: 1.0 You Are (Not) Alone | 2007 Japanese animated science fiction film | 1 |
| Evangelion: 2.0 You Can (Not) Advance | 2009 Japanese animated film | 1 |
| Evil Under the Sun | 1941 novel by Agatha Christie | 1 |
| Excalibur | 1981 film by John Boorman | 1 |
| Executive Orders | novel by Tom Clancy | 1 |
| Exiles | 1990 book by Howard Weinstein | 5 |
| Ex Machina | 2014 film directed by Alex Garland | 1 |
| Exodus | poem in the Junius manuscript | 1 |
| Exodus | second book of the Bible | 2 |
| Exodus: Gods and Kings | 2014 film directed by Ridley Scott | 1 |
| Eyeless in Gaza | novel by Aldous Huxley | 3 |
| Ezekiel | book of the Bible | 4 |
| Ezel | Turkish TV series | 4 |
| Fables | comic book series | 1 |
| Faces of Fire | book by Michael Jan Friedman | 5 |
| Fahrenheit 451 | 1953 novel by Ray Bradbury | 1 |
| Fairy Tail | Japanese manga series | 6 |
| Fairy Tail | Japanese anime television series | 5 |
| Fairy Tail: 100 Years Quest | Japanese web manga series | 4 |
| Fairy Tail the Movie: Dragon Cry | 2017 animated film produced by A-1 Pictures | 5 |
| Fairy Tail the Movie: Phoenix Priestess | 2012 anime film produced by A-1 Pictures | 5 |
| Fallen Heroes | Book by Dafydd ab Hugh, from 1994 | 5 |
| Fall of Eagles | 1974 British television series | 1 |
| Fallout | American television series | 2 |
| Fallout | 1997 action role-playing video game | 5 |
| Fallout 2 | 1998 video game | 6 |
| Fallout 4 | 2015 action role-playing video game | 19 |
| Fallout: New Vegas | 2010 action role-playing video game | 17 |
| Fallout Shelter | simulation video game | 2 |
| Fallout: The Board Game | narrative-based adventure board game | 1 |
| Falstaff | opera by Giuseppe Verdi | 1 |
| Family Guy | An American animated sitcom created by Seth MacFarlane | 9 |
| Family Matters | television series | 1 |
| Family Ties | television series | 1 |