| Work | Description | Characters |
|---|---|---|
| Dissidia Final Fantasy | video game | 3 |
| Dissidia Final Fantasy NT | fighting game with action role-playing elements | 4 |
| Dissidia Final Fantasy Opera Omnia | 2017 video game | 3 |
| District 9 | 2009 film directed by Neill Blomkamp | 1 |
| Divine Principle | Exposition of the Divine Principle | 3 |
| Django | 1966 film directed by Sergio Corbucci | 1 |
| Django 2 | 1987 film by Nello Rossati | 1 |
| Django Unchained | 2012 film by Quentin Tarantino | 1 |
| DmC: Devil May Cry | 2013 video game | 2 |
| Do Androids Dream of Electric Sheep? | 1968 novel by Philip K. Dick | 1 |
| Dōbutsu no Mori | 2005 film | 2 |
| Dōbutsu Takarajima | 1971 film by Hiroshi Ikeda | 1 |
| Do Comets Dream? | Book by S. P. Somtow, from 2003 | 5 |
| Doctor Sleep | 2019 film by Mike Flanagan | 2 |
| Doctor Sleep | novel by Stephen King | 2 |
| Doctor's Orders | book by Diane Duane | 5 |
| Doctor Strange | 2016 film directed by Scott Derrickson | 6 |
| Doctor Strange | 1968 comic book series | 1 |
| Doctor Strange in the Multiverse of Madness | upcoming superhero film produced by Marvel Studios | 3 |
| Doctor Strange: The Sorcerer Supreme | 2007 film by Patrick Archibald | 1 |
| Doctor Who | British science fiction TV series (1963-1989 and since 2005) | 6 |
| Dog Days | Japanese anime television series | 1 |
| Dogma | 1999 film by Kevin Smith | 1 |
| Doki Doki Literature Club! | 2017 horror visual novel developed by Team Salvato | 5 |
| Dollars Trilogy | 1964–1966 Western films directed by Sergio Leone | 1 |
| Donald Duck and urban climbers | P.I.A agents Donald and Paperoga climb a building to foil a criminal plan | 2 |
| Don Giovanni | opera by Wolfgang Amadeus Mozart | 1 |
| Don Juan | satiric poem by Lord Byron | 1 |
| Don Juan | 1926 film by Alan Crosland | 1 |
| Donkey Kong Jr. | 1982 arcade game | 1 |
| Don Quixote | novel by the Spanish author Miguel de Cervantes Saavedra | 2 |
| Don Quixote | 1915 film by Edward Dillon | 1 |
| Dooku: Jedi Lost | audio-only novel by Cavan Scott | 2 |
| Doom | series of video games and other media | 1 |
| Doom Patrol | comic book series | 1 |
| Doomsday Clock | DC Comics Limited Series (2017-2019) | 3 |
| Doomsday World | Book | 5 |
| Doonesbury | comic strip | 1 |
| Dora and the Lost City of Gold | 2019 film directed by James Bobin | 1 |
| Doraemon | Japanese manga and anime series | 1 |
| Dora the Explorer | American animated television series | 1 |
| Dorohedoro | Japanese anime television series | 1 |
| Dorohedoro | Japanese manga series | 1 |
| Dota 2 | 2013 multiplayer online battle arena video game | 5 |
| Double Dealing Character | scrolling shooter video game | 1 |
| Double, Double | novel by Michael Jan Friedman | 5 |
| Dracula | 1897 Gothic horror novel by Irish author Bram Stoker | 4 |
| Dracula | 2002 movie | 2 |
| Dragon Age II | video game | 3 |
| Dragon Age: Inquisition | 2014 video game | 4 |
| Dragon Age: Origins | 2009 video game | 2 |
| Dragon Ball | Japanese media franchise | 22 |
| Dragon Ball | Japanese manga by Akira Toriyama | 4 |
| Dragon Ball | 1986-1989 Japanese anime television series | 7 |
| Dragon Ball Daima | Japanese anime television series | 1 |
| Dragonball Evolution | 2009 film by James Wong | 2 |
| Dragon Ball GT | 1997 Japanese anime television series | 16 |
| Dragon Ball Heroes | 2010 video game | 4 |
| Dragon Ball Legends | 2018 video game | 2 |
| Dragon Ball: Revenge of King Piccolo | video game | 1 |
| Dragon Ball Super | manga series within the larger Dragon Ball manga series | 1 |
| Dragon Ball Super | Japanese anime television series | 23 |
| Dragon Ball Z | 1989-1996 Japanese anime television series based on the Dragon Ball manga series | 26 |
| Dragon Ball Z: Budokai Tenkaichi 2 | 2006 video game | 1 |
| Dragon Ball Z: Cooler's Revenge | 1991 film by Mitsuo Hashimoto | 1 |
| Dragon Ball Z: Dokkan Battle | 2015 video game | 1 |
| Dragon Ball Z: Fusion Reborn | 1995 anime film directed by Shigeyasu Yamauchi | 1 |
| Dragon Ball Z Kai | 2009 anime television series | 15 |
| Dragon Ball Z: Resurrection 'F' | 2015 film | 1 |
| Dragonlance | fictional universe | 1 |
| Dragon's Dogma Online | 2015 video game | 2 |
| Dragon's Honor | Book by Kij Johnson and Greg Cox, from 1996 | 5 |
| Dreadnought! | novel by Diane Carey | 1 |
| Dreams Of The Raven | novel by Carmen Carter | 5 |
| DreamWorks Dragons | American animated television series | 1 |
| Dr. Jekyll and Mr. Hyde | 1941 American horror film directed by Victor Fleming | 2 |
| Dr. Jekyll and Mr. Hyde | 1920 horror film, directed by J. Charles Haydon | 2 |
| Dr. Jekyll and Mr. Hyde | 1931 film by Rouben Mamoulian | 2 |
| Dr. Jekyll and Mr. Hyde | 1910 film by August Blom | 2 |
| Dr. Jekyll and Mr. Hyde | 1920 film, directed by John S. Robertson | 2 |
| Dr. Jekyll and Mr. Hyde | 1913 American film directed by Herbert Brenon | 2 |
| Dr. Jekyll and Mr. Hyde | 1912 film by Lucius J. Henderson produced by Thanhouser Company | 2 |
| Dr. Jekyll and Mr. Hyde | 1908 film by Otis Turner | 2 |
| Dr. Mario | 1990 arcade action puzzle video game | 1 |
| Dr. Mario Online Rx | video game | 1 |
| Dr. No | film in the James Bond series | 1 |
| Dr. Seuss' How the Grinch Stole Christmas | 2000 film by Ron Howard | 2 |
| Dr. Seuss' How the Grinch Stole Christmas! | 1966 American animated television special based on the book by Dr. Seuss | 1 |
| Dr. Stone | Japanese manga series | 2 |
| Dr. Stone | Japanese anime television series | 2 |
| Dr. Strange | 1978 film directed by Philip DeGuere | 1 |
| DuckTales | 2017 reboot of the 1987 American animated series | 1 |
| Duke Nukem | video game series | 1 |
| Dumb Witness | book | 1 |
| Dune | 1965 science fiction novel by Frank Herbert | 8 |
| Dune | 2021 film directed by Denis Villeneuve | 1 |
| Dune | 1984 American epic science fiction film by David Lynch | 1 |
| Dune Messiah | novel by Frank Herbert | 1 |
| Dune novel series | science fiction novel series by Frank Herbert | 8 |
| Dune: Part Two | 2024 film directed by Denis Villeneuve | 1 |