| Work | Description | Characters |
|---|---|---|
| Stranger Things, season 1 | season of television series | 10 |
| Stranger Things, season 2 | season of television series | 12 |
| Stranger Things, season 3 | third season of Netflix series Stranger Things | 12 |
| Stranger Things, season 4 | fourth season of Netflix series Stranger Things | 1 |
| Strange Tales | Marvel Comics anthology series | 1 |
| Strawberry Marshmallow | Japanese manga series | 1 |
| Strawberry Marshmallow | Japanese anime television series | 1 |
| Street Fighter | video game series | 3 |
| Street Fighter Alpha 2 | 1996 arcade video game | 1 |
| Street Fighter Alpha 3 | 1998 arcade video game | 1 |
| Street Fighter III: 2nd Impact | 1997 arcade video game | 1 |
| Street Fighter III: 3rd Strike | 1999 arcade video game | 1 |
| Street Fighter IV | 2008 video game | 1 |
| Street Fighter X Mega Man | video game | 1 |
| Street Fighter X Tekken | video game | 1 |
| Strike Zone | novel by Peter David | 5 |
| Subterranean Animism | video game | 3 |
| Succession | American comedy-drama television series | 8 |
| Suicide Squad | 2016 American superhero film directed by David Ayer | 6 |
| Suits | American television drama series | 5 |
| Sumerian King List | Mesopotamian literary composition | 1 |
| Summer Heights High | Australian television series | 1 |
| Summer's Last Will and Testament | play written by Thomas Nashe | 1 |
| Summon the Thunder | book by Dayton Ward | 2 |
| Superbad | 2007 film by Greg Mottola | 1 |
| Superboy | comic book published by DC Comics | 1 |
| Superboy | US TV series | 2 |
| Super Dragon Ball Heroes | Japanese ONA series | 2 |
| Super Friends | American animated television series about a team of superheroes, which ran from 1973 to 1986 | 5 |
| Super Friends | television series | 1 |
| Super Friends: The Legendary Super Powers Show | television series | 1 |
| Supergirl | 1984 film directed by Jeannot Szwarc | 1 |
| Supergirl | 2015 American superhero TV series | 8 |
| Superhero Fight Club | 2015 short film | 1 |
| Superhero Fight Club 2.0 | 2016 short film | 3 |
| Superjail! | American animated television series | 1 |
| Super Luigi Bros. | redux of Super Mario Bros. | 1 |
| Superman | Atari 2600 game designed by John Dunn | 2 |
| Superman | 1948 15-part black-and-white Columbia film serial based on the comic book character Superman | 1 |
| Superman | series of seventeen animated Technicolor short films released by Paramount Pictures | 1 |
| Superman | 1988 animated television series | 1 |
| Superman | comic book series featuring Superman | 1 |
| Superman | video game released by Sunsoft | 1 |
| Superman | NES video game based on the popular DC Comics character and the first two films of the same name | 2 |
| Superman | arcade Beat 'em up/Shoot 'em up game | 1 |
| Superman | 1999 adventure video game developed and published by Titus Software for the Nintendo 64 video game console | 2 |
| Superman | 1978 superhero film directed by Richard Donner | 2 |
| Superman and the Mole Men | 1951 superhero film directed by Lee Sholem | 1 |
| Superman/Batman: Apocalypse | 2010 American direct-to-video animated superhero film directed by Lauren Montgomery | 3 |
| Superman/Batman: Public Enemies | 2009 film directed by Sam Liu | 2 |
| Superman: Brainiac Attacks | 2006 film by Curt Geda | 2 |
| Superman: Countdown to Apokolips | 2003 video game | 2 |
| Superman: Doomsday | 2007 animated film | 1 |
| Superman II | 1980 superhero film by Richard Lester | 2 |
| Superman III | 1983 superhero action comedy film directed by Richard Lester | 2 |
| Superman II: The Richard Donner Cut | 2006 film by Richard Donner, Richard Lester | 1 |
| Superman IV: The Quest for Peace | 1987 superhero film directed by Sidney J. Furie | 1 |
| Superman & Lois | 2021 American superhero drama television series | 1 |
| Superman Returns | video game loosely based on the movie of the same name | 1 |
| Superman Returns | 2006 superhero film directed by Bryan Singer | 2 |
| Superman Returns: Fortress of Solitude | 2006 video game | 1 |
| Superman: Shadow of Apokolips | 2002 video game | 1 |
| Superman/Shazam!: The Return of Black Adam | 2010 film directed by Joaquim Dos Santos | 1 |
| Superman: The Animated Series | television series | 7 |
| Superman: The Game | 1985 game published in the US by First Star Software for the Commodore 64 | 2 |
| Superman: The Man of Steel | 2002 video game | 1 |
| Superman: The Man of Steel (1989 video game) | 1989 video game | 1 |
| Superman: Unbound | 2013 film directed by James Tucker | 3 |
| Superman vs. The Elite | 2012 film directed by Michael Chang | 1 |
| Super Mario | video game franchise | 3 |
| Super Mario 3D Land | platform video game developed by Nintendo for the Nintendo 3DS in 2011 | 1 |
| Super Mario 3D World | 2013 platform video game developed by Nintendo | 1 |
| Super Mario 64 | 1996 platform video game developed by Nintendo | 1 |
| Super Mario 64 DS | 2004 platform video game developed by Nintendo | 1 |
| Super Mario Bros. | 1985 platform video game | 1 |
| Super Mario Bros. 2 | 1988 platform video game developed by Nintendo | 3 |
| Super Mario Bros. 3 | 1988 platform video game developed by Nintendo | 4 |
| Super Mario Bros.: The Lost Levels | 1986 video game developed by Nintendo | 2 |
| Super Mario Galaxy | 2007 platform video game | 4 |
| Super Mario Galaxy 2 | 2010 platforming video game | 1 |
| Super Mario Kart | 1992 racing video game | 4 |
| Super Mario Land 2: 6 Golden Coins | 1992 video game for the Game Boy | 2 |
| Super Mario Maker | 2015 level editor video game developed by Nintendo EAD | 2 |
| Super Mario Maker 2 | 2019 level editor video game developed by Nintendo | 1 |
| Super Mario Odyssey | 2017 3D open-world platformer video game developed by Nintendo | 4 |
| Super Mario Party | 2018 party video game | 5 |
| Super Mario RPG | 1996 action role-playing game | 1 |
| Super Mario Run | 2016 auto-running Mario smartphone mobile game | 1 |
| Super Mario World | 1990 platform video game developed by Nintendo | 4 |
| Supernatural | TV series | 4 |
| Super Paper Mario | 2007 video game | 4 |
| Super Princess Peach | 2005 video game | 3 |
| Super Seisyun Brothers | Japanese manga series | 1 |
| Super Seisyun Brothers | Japanese anime television series | 1 |
| Super Smash Bros. | 1999 video game | 3 |
| Super Smash Bros. | video game series | 14 |
| Super Smash Bros. Brawl | 2008 crossover fighting video game | 4 |
| Super Smash Bros. for Nintendo 3DS and Wii U | conflation of several 2014 fighting video games on different platforms | 2 |
| Super Smash Bros. Melee | crossover fighting video game developed by Nintendo for the Nintendo GameCube in 2001 | 4 |
| Super Smash Bros. Ultimate | 2018 fighting video game | 5 |