| Work | Description | Characters |
|---|---|---|
| Star Wars: The Clone Wars | 2008 film by Dave Filoni | 6 |
| Star Wars: The Clone Wars | 2008 American television series | 19 |
| Star Wars: The Force Awakens | 2015 American epic space opera film directed by J. J. Abrams | 9 |
| Star Wars: The Force Unleashed | 2008 video game | 1 |
| Star Wars: The Old Republic | 2011 video game | 1 |
| Star Wars: The Old Republic: Revan | 2011 novel | 1 |
| Star Wars: The Paradise Snare | book by Ann C. Crispin | 1 |
| Star Wars: Thrawn | book | 2 |
| Star Wars: TIE Fighter | 1994 video game | 1 |
| Star Wars: Yoda Stories | video game | 1 |
| Starwatching | 428th strip of the webcomic xkcd | 1 |
| Static Shock | US 2000-2004 animated TV series | 6 |
| Station 19 | American action-drama television series | 1 |
| Station Rage | Book by Diane Carey, from 1995 | 6 |
| Steamboat Willie | 1928 Mickey Mouse cartoon | 1 |
| Steins;Gate | 2011 anime television series directed by Kanji Wakabayashi | 3 |
| Steins;Gate | 2009 video game | 8 |
| Steins;Gate | manga | 3 |
| Step by Step | American sitcom | 1 |
| Stephen Hero | unpublished novel by James Joyce | 1 |
| Steven Universe | American animated television series | 9 |
| Still Game | BBC television program | 7 |
| Stitch! | 2008 Japanese anime television spin-off of Disney's Lilo & Stitch franchise | 2 |
| Stitch & Ai | 2017 Chinese animated series spin-off in the Lilo & Stitch franchise | 1 |
| Stitch! The Movie | 2003 direct-to-video pilot film | 4 |
| St. Nicholas | painting by Robert Walter Weir, multiple versions in various collections | 1 |
| Stone Ocean | the sixth story arc of the Japanese manga series JoJo's Bizarre Adventure, written and illustrated by Hirohiko Araki | 2 |
| Stopping the Show | 1932 film by Dave Fleischer | 1 |
| Stop That Noise | 1935 film by Dave Fleischer | 1 |
| Stormbringer! | book by Michael Moorcock | 1 |
| Storm Clouds Gather | Mission in Star Trek: Online | 1 |
| Storming Heaven | Book by David Alan Mack, from 2012 | 5 |
| Stormrage | Novel | 2 |
| Story of Eastern Wonderland | The second game of the Touhou Project, a series of bullet hell shoot-em-ups. | 1 |
| Strange Bedfellows | episode of Star Trek: Deep Space Nine (S7 E19) | 1 |
| Strange Case of Dr Jekyll and Mr Hyde | novella by Robert Louis Stevenson | 3 |
| Strangers from the Sky | book by Margaret Wander Bonanno | 3 |
| Stranger Things | American science fiction horror Netflix series | 21 |
| Stranger Things, season 1 | season of television series | 10 |
| Stranger Things, season 2 | season of television series | 12 |
| Stranger Things, season 3 | third season of Netflix series Stranger Things | 12 |
| Stranger Things, season 4 | fourth season of Netflix series Stranger Things | 1 |
| Strange Tales | Marvel Comics anthology series | 1 |
| Strawberry Marshmallow | Japanese manga series | 1 |
| Strawberry Marshmallow | Japanese anime television series | 1 |
| Street Fighter | video game series | 3 |
| Street Fighter Alpha 2 | 1996 arcade video game | 1 |
| Street Fighter Alpha 3 | 1998 arcade video game | 1 |
| Street Fighter III: 2nd Impact | 1997 arcade video game | 1 |
| Street Fighter III: 3rd Strike | 1999 arcade video game | 1 |
| Street Fighter IV | 2008 video game | 1 |
| Street Fighter X Mega Man | video game | 1 |
| Street Fighter X Tekken | video game | 1 |
| Strike Zone | novel by Peter David | 5 |
| Subterranean Animism | video game | 3 |
| Succession | American comedy-drama television series | 8 |
| Suicide Squad | 2016 American superhero film directed by David Ayer | 6 |
| Suits | American television drama series | 5 |
| Sumerian King List | Mesopotamian literary composition | 1 |
| Summer Heights High | Australian television series | 1 |
| Summer's Last Will and Testament | play written by Thomas Nashe | 1 |
| Summon the Thunder | book by Dayton Ward | 2 |
| Superbad | 2007 film by Greg Mottola | 1 |
| Superboy | US TV series | 2 |
| Superboy | comic book published by DC Comics | 1 |
| Super Dragon Ball Heroes | Japanese ONA series | 2 |
| Super Friends | television series | 1 |
| Super Friends | American animated television series about a team of superheroes, which ran from 1973 to 1986 | 5 |
| Super Friends: The Legendary Super Powers Show | television series | 1 |
| Supergirl | 2015 American superhero TV series | 8 |
| Supergirl | 1984 film directed by Jeannot Szwarc | 1 |
| Superhero Fight Club | 2015 short film | 1 |
| Superhero Fight Club 2.0 | 2016 short film | 3 |
| Superjail! | American animated television series | 1 |
| Super Luigi Bros. | redux of Super Mario Bros. | 1 |
| Superman | comic book series featuring Superman | 1 |
| Superman | arcade Beat 'em up/Shoot 'em up game | 1 |
| Superman | 1948 15-part black-and-white Columbia film serial based on the comic book character Superman | 1 |
| Superman | 1978 superhero film directed by Richard Donner | 2 |
| Superman | 1999 adventure video game developed and published by Titus Software for the Nintendo 64 video game console | 2 |
| Superman | series of seventeen animated Technicolor short films released by Paramount Pictures | 1 |
| Superman | NES video game based on the popular DC Comics character and the first two films of the same name | 2 |
| Superman | Atari 2600 game designed by John Dunn | 2 |
| Superman | video game released by Sunsoft | 1 |
| Superman | 1988 animated television series | 1 |
| Superman and the Mole Men | 1951 superhero film directed by Lee Sholem | 1 |
| Superman/Batman: Apocalypse | 2010 American direct-to-video animated superhero film directed by Lauren Montgomery | 3 |
| Superman/Batman: Public Enemies | 2009 film directed by Sam Liu | 2 |
| Superman: Brainiac Attacks | 2006 film by Curt Geda | 2 |
| Superman: Countdown to Apokolips | 2003 video game | 2 |
| Superman: Doomsday | 2007 animated film | 1 |
| Superman II | 1980 superhero film by Richard Lester | 2 |
| Superman III | 1983 superhero action comedy film directed by Richard Lester | 2 |
| Superman II: The Richard Donner Cut | 2006 film by Richard Donner, Richard Lester | 1 |
| Superman IV: The Quest for Peace | 1987 superhero film directed by Sidney J. Furie | 1 |
| Superman & Lois | 2021 American superhero drama television series | 1 |
| Superman Returns | 2006 superhero film directed by Bryan Singer | 2 |
| Superman Returns | video game loosely based on the movie of the same name | 1 |
| Superman Returns: Fortress of Solitude | 2006 video game | 1 |
| Superman: Shadow of Apokolips | 2002 video game | 1 |