| Work | Description | Characters |
|---|---|---|
| Spider-Man trilogy | film trilogy by Sam Raimi | 1 |
| Spider-Man: Web of Shadows | 2008 video game | 2 |
| Spirited Away | episode of Avatar: The Last Airbender (S1 E5) | 1 |
| Spirited Away | 2001 Japanese animated film directed by Hayao Miyazaki | 7 |
| Splinter of Ice | short story by Andrzej Sapkowski | 1 |
| Split | 2017 film by M. Night Shyamalan | 2 |
| Spock, Messiah! | novel | 4 |
| Spock Must Die! | novel | 5 |
| Spock's World | book by Diane Duane | 4 |
| SpongeBob SquarePants | American animated television series | 10 |
| SpongeBob SquarePants: Battle for Bikini Bottom | 2003 video game | 2 |
| SpongeBob SquarePants featuring Nicktoons: Globs of Doom | video game | 1 |
| SpongeBob SquarePants: Lights, Camera, Pants! | 2005 video game | 1 |
| SpongeBob SquarePants: Revenge of the Flying Dutchman | 2002 video game | 1 |
| Spy × Family | Japanese anime television series | 3 |
| Spy × Family | Japanese manga series | 3 |
| Squid Game | 2021 South Korean Netflix TV series | 13 |
| Squid Girl | Japanese manga series | 1 |
| Squid Girl | Japanese anime television series | 1 |
| StarCraft | 1998 video game | 1 |
| StarCraft II: Wings of Liberty | real-time strategy game from the year 2010 | 2 |
| Stardew Valley | 2016 indie farming simulation role-playing video game | 14 |
| Stardust City Rag | 5th Episode of Star Trek: Picard | 5 |
| Stardust Crusaders | the third story arc of the Japanese manga series JoJo's Bizarre Adventure, written and illustrated by Hirohiko Araki | 3 |
| Stargate | 1994 American-French science fiction film directed by Roland Emmerich | 1 |
| Stargate Atlantis | science fiction tv-show | 3 |
| Stargate: Continuum | 2008 film by Martin Wood | 4 |
| Stargate SG-1 | science fiction TV show (1997–2007) | 4 |
| Stargate: The Ark of Truth | 2008 film by Robert C. Cooper | 4 |
| Stargate Universe | Canadian-American military science fiction TV series | 3 |
| Star Ocean: Anamnesis | 2016 video game | 2 |
| Starship Troopers | 1988 original video animation | 1 |
| Starship Troopers | 1997 film directed by Paul Verhoeven | 2 |
| Starship Troopers | first-person shooter game | 1 |
| Starship Troopers | 1959 novel by Robert A. Heinlein | 1 |
| Starship Troopers 3: Marauder | 2008 film by Edward Neumeier | 1 |
| Starship Troopers: Invasion | 2012 film by Shinji Aramaki | 1 |
| Star Trek | science fiction media franchise | 7 |
| Star Trek | 2009 novel by Alan Dean Foster | 1 |
| Star Trek: Adversaries | Star Trek Videogame, and collectible card video game for Microsoft Windows and macOS | 1 |
| Star Trek Beyond | 2016 American science fiction film directed by Justin Lin | 1 |
| Star Trek: Birth of the Federation | computer strategy game | 1 |
| Star Trek: Deep Space Nine | American science fiction television series from 1993–1999 | 29 |
| Star Trek: Deep Space Nine Technical Manual | Book | 9 |
| Star Trek Fleet Command | 2018 mobile video game | 3 |
| Star Trek Into Darkness | 2013 Star Trek novel by Alan Dean Foster | 1 |
| Star Trek Into Darkness | 2013 American science fiction action film directed by J. J. Abrams | 1 |
| Star Trek: New Worlds | 2000 video game | 1 |
| Star Trek: Picard | American web television series | 1 |
| Star Trek: Starfleet Command | 1999 video game | 1 |
| Star Trek: Starship Creator | 1998 video game | 35 |
| Star Trek: The Motion Picture | novelization of the film Star Trek: The Motion Picture | 5 |
| Star Trek: The Next Generation | American science fiction television series from 1987–1994 | 1 |
| Star Trek: The Original Series | American science fiction television series | 7 |
| Star Trek: The Original Series Core Game Book | 3 | |
| Star Trek Trexels | 2013 video game based on Star Trek | 18 |
| Star Trek: Voyager | American science fiction television series from 1995–2001 | 11 |
| Star vs. the Forces of Evil | American animated television series | 1 |
| Star Wars | epic science fantasy space opera saga and media franchise | 16 |
| Star Wars: Ahsoka | 2016 novel | 1 |
| Star Wars Battlefront | action shooter video game published by Electronic Arts in 2015 | 3 |
| Star Wars Battlefront II | 2017 first- and third-person shooter video game developed by EA DICE | 15 |
| Star Wars: Battlefront II (2005 video game) | 2005 shooter video game based on the Star Wars film franchise published by LucasArts | 4 |
| Star Wars: Clone Wars | American animated television series | 7 |
| Star Wars: Darth Bane: Dynasty of Evil | book | 1 |
| Star Wars: Darth Bane: Path of Destruction | book | 1 |
| Star Wars: Darth Bane: Rule of Two | book | 1 |
| Star Wars: Darth Plagueis | 2012 book | 2 |
| Star Wars: Droids | American animated television series | 1 |
| Star Wars Episode I | 1999 video game, pinball | 1 |
| Star Wars: Episode II – Attack of the Clones | 2002 American epic space opera film directed by George Lucas | 10 |
| Star Wars: Episode III – Revenge of the Sith | 2005 American epic space opera film directed by George Lucas | 13 |
| Star Wars Episode I: Racer | 1999 racing game | 1 |
| Star Wars Episode I: The Phantom Menace | 1999 novel | 1 |
| Star Wars: Episode I – The Phantom Menace | 1999 American epic space opera film directed by George Lucas | 9 |
| Star Wars: Episode I – The Phantom Menace (video game) | 1999 video game | 2 |
| Star Wars Episode IV: A New Hope | 1977 American epic space opera film directed by George Lucas | 7 |
| Star Wars Episode IX: The Rise of Skywalker | 2019 Star Wars film directed by J. J. Abrams | 6 |
| Star Wars: Episode VIII – The Last Jedi | 2017 American epic space opera film directed by Rian Johnson | 8 |
| Star Wars Episode V: The Empire Strikes Back | 1980 science fiction film directed by Irvin Kershner | 10 |
| Star Wars: Force Arena | 2017 Star Wars-themed mobile game | 1 |
| Star Wars Forces of Destiny | television series | 2 |
| Star Wars: Galactic Defense | 2014 video game | 1 |
| Star Wars Galaxies | 2003 video game | 6 |
| Star Wars Galaxies: Trials of Obi-Wan | 2005 video game | 1 |
| Star Wars: Galaxy of Heroes | 2015 mobile game | 1 |
| Star Wars Jedi: Fallen Order | 2019 single-player action-adventure video game | 1 |
| Star Wars Jedi Knight II: Jedi Outcast | video game | 1 |
| Star Wars Jedi: Survivor | 2023 video game developed by Respawn Entertainment | 1 |
| Star Wars: Knights of the Old Republic | video game series | 1 |
| Star Wars: Knights of the Old Republic | 2003 video game | 2 |
| Star Wars Knights of the Old Republic II: The Sith Lords | 2004 video game | 3 |
| Star Wars: Masters of Teräs Käsi | video game | 6 |
| Star Wars original trilogy | film trilogy | 2 |
| Star Wars prequel trilogy | second film trilogy in the Star Wars franchise | 1 |
| Star Wars Rebels | American 3D CGI animated television series from 2014 | 11 |
| Star Wars Resistance | 2018 animated television series by Dave Filoni | 1 |
| Star Wars sequel trilogy | third film trilogy in the Star Wars franchise | 2 |
| Star Wars: Tarkin | book by James Luceno | 1 |
| Star Wars: The Bad Batch | animated series | 4 |