| Work | Description | Characters |
|---|---|---|
| Sonic & Knuckles Collection | 1997 video game compilation | 1 |
| Sonic Mania | 2017 platform video game | 4 |
| Sonic Riders | video game | 2 |
| Sonic Riders: Zero Gravity | 2008 racing video game | 2 |
| Sonic Rivals | 2006 video game | 2 |
| Sonic Rivals 2 | 2007 video game | 2 |
| Sonic & Sega All-Stars Racing | 2010 video game | 1 |
| Sonic the Hedgehog | Sega video game series and associated media franchise | 7 |
| Sonic the Hedgehog | 2006 video game by Sega | 8 |
| Sonic the Hedgehog | 2020 film directed by Jeff Fowler | 2 |
| Sonic the Hedgehog 2 | 2022 film directed by Jeff Fowler | 1 |
| Sonic the Hedgehog 3 | 2024 film directed by Jeff Fowler | 1 |
| Sonic the Hedgehog CD | 1993 video game | 3 |
| Sonic X | 2003 Anime television series directed by Hajime Kamegaki | 4 |
| Son of Batman | 2014 animated feature film directed by Ethan Spaulding | 2 |
| Sons of Anarchy | American television series | 4 |
| Sony's Spider-Man Universe | shared fictional universe | 1 |
| Soulcalibur | video game series | 1 |
| Soulcalibur II | 2002 video game | 1 |
| Soulcalibur IV | video game | 1 |
| Soul Eater | Japanese anime television series | 2 |
| Soul Eater | Japanese manga series | 2 |
| Soul Eater Not! | Japanese manga series | 1 |
| Soul Eater Not! | Japanese anime television series | 1 |
| Soul Reaver 2 | 2001 video game | 1 |
| South Park | American animated sitcom | 13 |
| South Park: The Fractured But Whole | video game | 1 |
| Space Ghost | animated television series | 1 |
| Space Ghost Coast to Coast | American animated parody talk show | 2 |
| Space Jam: A New Legacy | 2021 live-action and animated sports comedy film by Malcolm D. Lee | 4 |
| Space Patrol Luluco | Japanese anime television series | 1 |
| Spartacus | novel | 5 |
| Spartacus | American television series (2010-2013) | 6 |
| Spartacus: Gods of the Arena | Starz television miniseries and prequel to Spartacus | 1 |
| Spartacus: Vengeance | second season of Spartacus | 1 |
| Spartacus: War of the Damned | third season of Spartacus | 1 |
| Speaker for the Dead | novel by Orson Scott Card | 1 |
| Spectre | 2015 James Bond film by Sam Mendes | 1 |
| Spectre | book by William Shatner | 8 |
| Spice and Wolf | Japanese anime television series | 1 |
| Spider-Man | 2002 beat 'em up video game | 3 |
| Spider-Man | 2018 video game developed by Insomniac Game | 5 |
| Spider-Man | 1981 animated series | 1 |
| Spider-Man | 2000 video game | 2 |
| Spider-Man | 2002 superhero film directed by Sam Raimi, first installment in the Sam Raimi Spider-Man trilogy | 6 |
| Spider-Man | American animated television series from 1994–1998 | 6 |
| Spider-Man 2 | 2004 video game | 3 |
| Spider-Man 2 | 2004 superhero film directed by Sam Raimi | 6 |
| Spider-Man 2.1 | 2007 film by Sam Raimi | 1 |
| Spider-Man 2: Enter Electro | 2001 video game | 2 |
| Spider-Man 3 | 2007 US superhero film directed by Sam Raimi | 8 |
| Spider-Man 3 | 2007 video game | 8 |
| Spider-Man 3: Editor's Cut | 2017 film by Sam Raimi | 1 |
| Spider-Man and His Amazing Friends | American animated television series from 1981-1983 | 7 |
| Spider-Man and the X-Men in Arcade's Revenge | 1992 video game | 1 |
| Spider-Man: Edge of Time | 2011 video game | 1 |
| Spider-Man: Far from Home | 2019 superhero film produced by Marvel Studios | 5 |
| Spider-Man: Friend or Foe | 2007 video game | 2 |
| Spider-Man: Homecoming | 2017 superhero film produced by Marvel Studios | 5 |
| Spider-Man: Into the Spider-Verse | 2018 American computer-animated superhero film | 1 |
| Spider-Man: No Way Home | 2021 superhero film produced by Marvel Studios | 4 |
| Spider-Man: Shattered Dimensions | video game | 2 |
| Spider-Man trilogy | film trilogy by Sam Raimi | 1 |
| Spider-Man: Web of Shadows | 2008 video game | 2 |
| Spirited Away | episode of Avatar: The Last Airbender (S1 E5) | 1 |
| Spirited Away | 2001 Japanese animated film directed by Hayao Miyazaki | 7 |
| Splinter of Ice | short story by Andrzej Sapkowski | 1 |
| Split | 2017 film by M. Night Shyamalan | 2 |
| Spock, Messiah! | novel | 4 |
| Spock Must Die! | novel | 5 |
| Spock's World | book by Diane Duane | 4 |
| SpongeBob SquarePants | American animated television series | 10 |
| SpongeBob SquarePants: Battle for Bikini Bottom | 2003 video game | 2 |
| SpongeBob SquarePants featuring Nicktoons: Globs of Doom | video game | 1 |
| SpongeBob SquarePants: Lights, Camera, Pants! | 2005 video game | 1 |
| SpongeBob SquarePants: Revenge of the Flying Dutchman | 2002 video game | 1 |
| Spy × Family | Japanese anime television series | 3 |
| Spy × Family | Japanese manga series | 3 |
| Squid Game | 2021 South Korean Netflix TV series | 13 |
| Squid Girl | Japanese anime television series | 1 |
| Squid Girl | Japanese manga series | 1 |
| StarCraft | 1998 video game | 1 |
| StarCraft II: Wings of Liberty | real-time strategy game from the year 2010 | 2 |
| Stardew Valley | 2016 indie farming simulation role-playing video game | 14 |
| Stardust City Rag | 5th Episode of Star Trek: Picard | 5 |
| Stardust Crusaders | the third story arc of the Japanese manga series JoJo's Bizarre Adventure, written and illustrated by Hirohiko Araki | 3 |
| Stargate | 1994 American-French science fiction film directed by Roland Emmerich | 1 |
| Stargate Atlantis | science fiction tv-show | 3 |
| Stargate: Continuum | 2008 film by Martin Wood | 4 |
| Stargate SG-1 | science fiction TV show (1997–2007) | 4 |
| Stargate: The Ark of Truth | 2008 film by Robert C. Cooper | 4 |
| Stargate Universe | Canadian-American military science fiction TV series | 3 |
| Star Ocean: Anamnesis | 2016 video game | 2 |
| Starship Troopers | 1959 novel by Robert A. Heinlein | 1 |
| Starship Troopers | 1997 film directed by Paul Verhoeven | 2 |
| Starship Troopers | first-person shooter game | 1 |
| Starship Troopers | 1988 original video animation | 1 |
| Starship Troopers 3: Marauder | 2008 film by Edward Neumeier | 1 |
| Starship Troopers: Invasion | 2012 film by Shinji Aramaki | 1 |
| Star Trek | 2009 novel by Alan Dean Foster | 1 |