| Work | Description | Characters |
|---|---|---|
| Skyfall | 2012 James Bond film by Sam Mendes | 1 |
| Slam Dunk | Japanese manga series | 1 |
| Slayers | Japanese media franchise | 1 |
| Sleeping Beauty | 1959 American animated musical fantasy film produced by Walt Disney | 2 |
| Slippin' Jimmy | American animated comedy television series | 1 |
| Small Moral Works | work by Giacomo Leopardi | 1 |
| Smallville | American television series | 13 |
| Smallville (season 11) | 1 | |
| Smiley's People | book | 1 |
| Smiling Friends | Australian-American adult animated television series | 2 |
| Snowpiercer | American dystopian thriller television series | 2 |
| Snow White | 1933 film directed by Dave Fleischer | 1 |
| Snow White and the Seven Dwarfs | 1937 American animated film | 4 |
| So Does an Automobile | 1939 film by Dave Fleischer | 1 |
| Sofia the First | American animated television series | 1 |
| Solo: A Star Wars Story | 2018 American epic space opera film in the Star Wars franchise directed by Ron Howard | 4 |
| Solomon | oratorio by Georg Friedrich Händel | 1 |
| Solomon and Sheba | 1959 film | 1 |
| Solomon & Sheba | 1995 film by Robert M. Young | 1 |
| Something ends, Something begins | short story by Andrzej Sapkowski | 1 |
| Something Greater | short story by Andrzej Sapkowski | 1 |
| Song of Songs | book of the Bible | 1 |
| Sonic Advance | 2001 platform video game | 1 |
| Sonic Advance 2 | 2002 platform video game | 5 |
| Sonic Advance 3 | 2004 platform video game | 1 |
| Sonic Adventure | 1998 3D platforming video game developed by Sonic Team | 1 |
| Sonic Adventure 2 | 2001 platform video game | 3 |
| Sonic Adventure 2: Battle | 2002 video game | 1 |
| Sonic & All-Stars Racing Transformed | 2012 video game | 1 |
| Sonic and the Black Knight | 2009 platform video game | 1 |
| Sonic and the Secret Rings | 2007 platform video game | 1 |
| Sonic Battle | video game | 6 |
| Sonic Chronicles: The Dark Brotherhood | video game | 1 |
| Sonic Forces | 2017 video game | 9 |
| Sonic Free Riders | 2010 video game | 1 |
| Sonic Frontiers | 2022 platform video game developed by Sonic Team | 1 |
| Sonic Heroes | 2003 video game | 7 |
| Sonic & Knuckles | 1994 platform video game | 1 |
| Sonic & Knuckles Collection | 1997 video game compilation | 1 |
| Sonic Mania | 2017 platform video game | 4 |
| Sonic Riders | video game | 2 |
| Sonic Riders: Zero Gravity | 2008 racing video game | 2 |
| Sonic Rivals | 2006 video game | 2 |
| Sonic Rivals 2 | 2007 video game | 2 |
| Sonic & Sega All-Stars Racing | 2010 video game | 1 |
| Sonic the Hedgehog | Sega video game series and associated media franchise | 7 |
| Sonic the Hedgehog | 2006 video game by Sega | 8 |
| Sonic the Hedgehog | 2020 film directed by Jeff Fowler | 2 |
| Sonic the Hedgehog 2 | 2022 film directed by Jeff Fowler | 1 |
| Sonic the Hedgehog 3 | 2024 film directed by Jeff Fowler | 1 |
| Sonic the Hedgehog CD | 1993 video game | 3 |
| Sonic X | 2003 Anime television series directed by Hajime Kamegaki | 4 |
| Son of Batman | 2014 animated feature film directed by Ethan Spaulding | 2 |
| Sons of Anarchy | American television series | 4 |
| Sony's Spider-Man Universe | shared fictional universe | 1 |
| Soulcalibur | video game series | 1 |
| Soulcalibur II | 2002 video game | 1 |
| Soulcalibur IV | video game | 1 |
| Soul Eater | Japanese anime television series | 2 |
| Soul Eater | Japanese manga series | 2 |
| Soul Eater Not! | Japanese anime television series | 1 |
| Soul Eater Not! | Japanese manga series | 1 |
| Soul Reaver 2 | 2001 video game | 1 |
| South Park | American animated sitcom | 13 |
| South Park: The Fractured But Whole | video game | 1 |
| Space Ghost | animated television series | 1 |
| Space Ghost Coast to Coast | American animated parody talk show | 2 |
| Space Jam: A New Legacy | 2021 live-action and animated sports comedy film by Malcolm D. Lee | 4 |
| Space Patrol Luluco | Japanese anime television series | 1 |
| Spartacus | American television series (2010-2013) | 6 |
| Spartacus | novel | 5 |
| Spartacus: Gods of the Arena | Starz television miniseries and prequel to Spartacus | 1 |
| Spartacus: Vengeance | second season of Spartacus | 1 |
| Spartacus: War of the Damned | third season of Spartacus | 1 |
| Speaker for the Dead | novel by Orson Scott Card | 1 |
| Spectre | book by William Shatner | 8 |
| Spectre | 2015 James Bond film by Sam Mendes | 1 |
| Spice and Wolf | Japanese anime television series | 1 |
| Spider-Man | 2002 superhero film directed by Sam Raimi, first installment in the Sam Raimi Spider-Man trilogy | 6 |
| Spider-Man | American animated television series from 1994–1998 | 6 |
| Spider-Man | 1981 animated series | 1 |
| Spider-Man | 2018 video game developed by Insomniac Game | 5 |
| Spider-Man | 2000 video game | 2 |
| Spider-Man | 2002 beat 'em up video game | 3 |
| Spider-Man 2 | 2004 superhero film directed by Sam Raimi | 6 |
| Spider-Man 2 | 2004 video game | 3 |
| Spider-Man 2.1 | 2007 film by Sam Raimi | 1 |
| Spider-Man 2: Enter Electro | 2001 video game | 2 |
| Spider-Man 3 | 2007 US superhero film directed by Sam Raimi | 8 |
| Spider-Man 3 | 2007 video game | 8 |
| Spider-Man 3: Editor's Cut | 2017 film by Sam Raimi | 1 |
| Spider-Man and His Amazing Friends | American animated television series from 1981-1983 | 7 |
| Spider-Man and the X-Men in Arcade's Revenge | 1992 video game | 1 |
| Spider-Man: Edge of Time | 2011 video game | 1 |
| Spider-Man: Far from Home | 2019 superhero film produced by Marvel Studios | 5 |
| Spider-Man: Friend or Foe | 2007 video game | 2 |
| Spider-Man: Homecoming | 2017 superhero film produced by Marvel Studios | 5 |
| Spider-Man: Into the Spider-Verse | 2018 American computer-animated superhero film | 1 |
| Spider-Man: No Way Home | 2021 superhero film produced by Marvel Studios | 4 |
| Spider-Man: Shattered Dimensions | video game | 2 |