| Work | Description | Characters |
|---|---|---|
| Command & Conquer 4: Tiberian Twilight | video game | 1 |
| Command & Conquer: Red Alert | 1996 video game | 1 |
| Command & Conquer: Renegade | 2002 video game | 1 |
| Command & Conquer: The Covert Operations | expansion video game to the video game Command & Conquer | 1 |
| Communication Breakdown | Mission in Star Trek: Online | 1 |
| Community | American comedy television series created by Dan Harmon | 3 |
| Conan the Barbarian | collection of five fantasy short stories by American writer Robert E. Howard | 1 |
| Conan the Barbarian | collection of six fantasy short stories written by Robert E. Howard | 1 |
| Confessions of a Mask | novel by Yukio Mishima | 1 |
| Constantine | 2005 film by Francis Lawrence | 1 |
| Contamination | novel | 5 |
| Context is for Kings | episode of Star Trek: Discovery (S1 E3) | 2 |
| Cookie Run | 2013 video game | 5 |
| Cookie Run | Mobile game | 11 |
| Cookie Run: Kingdom | 2020 video game developed by Devsisters | 10 |
| Cookie Run: Ovenbreak | Video game developed by Devsisters | 6 |
| Cookie Run: Puzzle World | 2020 video game | 1 |
| CookieRun: Witch's Castle | 2024 video game | 2 |
| Copernicus | 1973 Polish film by Petelska and Czesław Petelski | 1 |
| Coraline | 2009 animated film directed by Henry Selick | 2 |
| Coraline | 2002 novella by Neil Gaiman | 1 |
| Corona | novel by Greg Bear | 4 |
| Coronation Street | British soap opera | 1 |
| Courage the Cowardly Dog | American children's animated television series | 3 |
| Covenant | episode of Star Trek: Deep Space Nine (S7 E9) | 9 |
| Cowboy Bebop | 1998 television anime series | 4 |
| Crash Landing on You | 2019-2020 South Korean television series | 2 |
| Crazy Ex-Girlfriend | American television series | 4 |
| Crime and Punishment | Russian-language novel by Dostoyevsky | 3 |
| Criminal Minds | 2005 American television series | 4 |
| Crimson Mist | 1 | |
| Crisis Core: Final Fantasy VII | video game | 3 |
| Crisis on Centaurus | book by Brad Ferguson | 4 |
| Crisis on Infinite Earths | Arrowverse crossover event | 2 |
| Crisis on Infinite Earths: Part Three | episode of The Flash (S6 E9) | 1 |
| Cristoforo Colombo | opera by Alberto Franchetti | 1 |
| "Crocodile" Dundee | 1986 Australian comedy film | 1 |
| "Crocodile" Dundee II | 1988 Australian adventure and comedy film directed by John Cornell | 1 |
| Crocodile Dundee in Los Angeles | 2001 Australian comedy film directed by Simon Wincer | 1 |
| Crooked Kingdom | 2016 novel by Leigh Bardugo | 2 |
| Crossfire | episode of Star Trek: Deep Space Nine (S4 E13) | 1 |
| Crossover | Book by Michael Jan Friedman | 8 |
| Crossroad | Book by Barbara Hambly, from 1994 | 5 |
| Cruel Intentions | 1999 film directed by Roger Kumble | 1 |
| Cruel Intentions 2 | 2000 film prequel of Cruel Intentions directed by Roger Kumble | 1 |
| Cruella | 2021 film directed by Craig Gillespie | 1 |
| CSI: Crime Scene Investigation | American crime fiction television series (2000–2015) | 2 |
| Cthulhu Mythos | fictional universe based on the work of H. P. Lovecraft | 2 |
| Curb Your Enthusiasm | American television series | 1 |
| Curious Alice | 1971 American animated short film | 1 |
| Curtain | detective fiction novel by Agatha Christie | 1 |
| Cyber Danganronpa VR: The Class Trial | virtual reality adventure video game | 1 |
| Cyberpunk 2077 | 2020 role-playing video game developed by CD Projekt RED | 1 |
| Cyberpunk: Edgerunners | Japanese ONA series | 1 |
| Cybersong | Book by Shariann Lewitt, from 1996 | 6 |
| Cycle of Hatred | book set in Warcraft video game world | 2 |
| Cyrano de Bergerac | play written in 1897 by Edmond Rostand | 1 |
| Cyropaedia | literary work | 1 |
| Cyrus the Great in the Bible | 1 | |
| Cyrus the Great in the Quran | the theory of Cyrus the Great being the character Dhul-Qarnayn in the Quran | 1 |
| Da Ali G Show | name of two related satirical TV series | 1 |
| Daedalus | Book by Dave Stern | 3 |
| Daedalus's Children | Book by Dave Stern | 3 |
| Daily Lives of High School Boys | Japanese manga series | 2 |
| Daily Lives of High School Boys | Japanese anime television series | 2 |
| Dance Dance Revolution: Mario Mix | 2005 musical video game | 1 |
| Danchigai | Japanese manga series | 1 |
| Danchigai | Japanese anime television series | 1 |
| Danganronpa | media franchise based on the eponymous video game series | 2 |
| Danganronpa 2: Goodbye Despair | Japanese mystery game | 6 |
| Danganronpa 3: The End of Hope's Peak High School | Japanese anime television series | 4 |
| Danganronpa 3: The End of Kibōgamine Gakuen THE STAGE 2018 | Japanese stage play based on the 2017 anime Danganronpa 3: The End of Hope's Peak High School | 1 |
| Danganronpa Another Episode: Ultra Despair Girls | 2014 video game | 1 |
| Danganronpa: The Animation | Japanese anime television series | 3 |
| Danganronpa: Trigger Happy Havoc | video game | 5 |
| Danganronpa V3: Killing Harmony | visual novel adventure game developed by Spike Chunsoft | 2 |
| Daniel 4 | Fourth chapter of the Book of Daniel | 1 |
| Danny Phantom | American animated television series | 1 |
| Daphne & Velma | 2018 American comedy mystery film directed by Suzi Yoonessi | 1 |
| Daredevil | 2003 movie based on the comic book directed by Mark Steven Johnson | 3 |
| Daredevil | 2015 American web television series | 6 |
| Daredevil: Born Again | upcoming TV series by Marvel Studios | 1 |
| Daredevil (Marvel Comics series) | 2 | |
| Daria | television series | 3 |
| Dark | 2017 German science fiction TV series | 14 |
| Dark Disciple | book by Christie Golden | 3 |
| Dark Empire | comic book series | 3 |
| Darker: Fifty Shades Darker as Told by Christian | erotic romance by British author, E. L. James | 1 |
| Darker than Black: Gemini of the Meteor | Japanese anime television series | 1 |
| Dark Force Rising | 1992 Star Wars novel by Timothy Zahn | 1 |
| Dark Mirror | book by Diane Duane | 5 |
| Darkness Falls | episode of The Legend of Korra (S2 E13) | 2 |
| Darkness on the Edge of Town | episode of Arrow | 1 |
| Dark Phoenix | 2019 superhero film directed by Simon Kinberg | 7 |
| Dark Souls | 2011 video game | 2 |
| Darkstalkers | video game series | 1 |
| Dark Victory | book by William Shatner | 8 |
| Darling in the Franxx | Japanese manga series | 1 |
| Darling in the Franxx | 2018 Japanese anime television series | 1 |
| Darth Maul: Son of Dathomir | 1 |