| Work | Description | Characters |
|---|---|---|
| Shameless | English comedy-drama series (2004-2013) | 4 |
| Shang-Chi and the Legend of the Ten Rings | 2021 superhero film produced by Marvel Studios | 2 |
| Shannara series | Series of books by Terry Brooks | 1 |
| Sharpe | British television series | 1 |
| Sharpe's Battle | book by Bernard Cornwell | 1 |
| Sharpe's Christmas | short story by Bernard Cornwell | 1 |
| Sharpe's Company | book by Bernard Cornwell | 1 |
| Sharpe's Devil | book by Bernard Cornwell | 1 |
| Sharpe's Eagle | book by Bernard Cornwell | 1 |
| Sharpe's Enemy | book by Bernard Cornwell | 1 |
| Sharpe's Escape | book | 1 |
| Sharpe's Fortress | book | 1 |
| Sharpe's Fury | book by Bernard Cornwell | 1 |
| Sharpe's Gold | book by Bernard Cornwell | 1 |
| Sharpe's Havoc | book | 1 |
| Sharpe's Honour | book by Bernard Cornwell | 1 |
| Sharpe's Prey | novel by Bernard Cornwell | 1 |
| Sharpe's Ransom | short story by Bernard Cornwell | 1 |
| Sharpe's Regiment | book by Bernard Cornwell | 1 |
| Sharpe's Revenge | book by Bernard Cornwell | 1 |
| Sharpe's Rifles | book by Bernard Cornwell | 1 |
| Sharpe's Siege | book by Bernard Cornwell | 1 |
| Sharpe's Skirmish | 1999 short story by Bernard Cornwell | 1 |
| Sharpe's Sword | book by Bernard Cornwell | 1 |
| Sharpe's Tiger | book | 1 |
| Sharpe's Trafalgar | book | 1 |
| Sharpe's Triumph | book | 1 |
| Sharpe's Waterloo | book by Bernard Cornwell | 1 |
| Shatterpoint | book by Matthew Stover | 1 |
| She-Hulk: Attorney at Law | 2022 American superhero television series | 1 |
| Shell Game | Book by Melissa Crandall, from 1993 | 5 |
| She-Ra and the Princesses of Power | American animated series | 4 |
| She-Ra: Princess of Power | American animated television series from 1985–1987 | 2 |
| Sherlock | British crime drama television series, first broadcast in 2010 | 8 |
| Sherlock Holmes | 2013 TV series | 1 |
| Sherlock Holmes | 2009 film by Guy Ritchie | 1 |
| Sherlock Holmes: A Game of Shadows | 2011 film by Guy Ritchie | 1 |
| Sherlockiana | non-canonical works involving Sherlock Holmes | 2 |
| She's Having a Baby | 1988 film by John Hughes | 1 |
| She Wronged Him Right | 1934 film by Dave Fleischer | 1 |
| Shiki | Japanese anime television series | 1 |
| Shiki | 2019 video game | 1 |
| Shimoneta | Japanese anime television series | 1 |
| Shimoneta: A Boring World Where the Concept of Dirty Jokes Doesn't Exist | Japanese light novel, manga, and anime series | 4 |
| Shindig | episode of Firefly (S1 E4) | 1 |
| Shin Megami Tensei: Nocturne | 2003 role-playing video game developed by Atlus | 1 |
| Shirobako | Japanese anime television series | 1 |
| Shirobako: The Movie | 2020 Japanese animated film by Tsutomu Mizushima | 1 |
| Shockwave | Star Trek: Enterprise novel | 3 |
| Shōgun | 1975 novel by James Clavell | 1 |
| Shoot the Bullet | video game | 2 |
| Shōwa Genroku Rakugo Shinjū | Japanese manga series | 1 |
| Showcase | title of several comic anthology series published by DC Comics | 2 |
| Shredder's New Sword | episode of the 1987–1996 Teenage Mutant Ninja Turtles animated television series | 2 |
| Shrek | 2001 animated comedy | 4 |
| Shrek 2 | video game | 3 |
| Shrek 2 | 2004 film directed by Andrew Adamson, Kelly Asbury and Conrad Vernon | 5 |
| Shrek 2: Team Action | 2004 video game | 3 |
| Shrek 4-D | 2003 4D film at various theme parks around the world | 2 |
| Shrek 5 | 2019 film directed by Andrew Adamson | 1 |
| Shrek Forever After | 2010 video game | 1 |
| Shrek Forever After | 2010 film directed by Mike Mitchell | 4 |
| Shrek: Hassle at the Castle | 2002 video game | 1 |
| Shrek Smash n' Crash Racing | 2006 video game | 1 |
| Shrek Super Party | 2002 video game | 1 |
| Shrek SuperSlam | 2005 video game | 5 |
| Shrek the Halls | 2007 television special directed by Gary Trousdale | 3 |
| Shrek the Third | 2007 film directed by Chris Miller | 5 |
| Shrek the Third | 2007 video game | 3 |
| Shrek universe | franchise | 1 |
| Shuggie Bain | 2020 novel by Douglas Stuart | 3 |
| Shugo Chara! | Japanese anime television series | 1 |
| Shugo Chara! | Japanese manga series | 1 |
| Siddhartha | novel by Hermann Hesse | 1 |
| Silas Marner | novel by George Eliot | 1 |
| Silent Hill | video game series | 2 |
| Silent Hill 2 | 2001 survival horror video game developed by Konami | 1 |
| Silicon Avatar | episode of Star Trek: The Next Generation (S5 E4) | 5 |
| Silicon Valley | 2014–2019 American television series | 3 |
| Silver Spoon | Japanese anime television series | 1 |
| Silver Spoon | Japanese manga series | 1 |
| Silver Surfer | comic book | 1 |
| Simpsons Comics | comic book series | 1 |
| Simpsorama | episode of The Simpsons (S26 E6) | 1 |
| Sin City | 2005 American crime thriller film written, produced and directed by Frank Miller and Robert Rodriguez | 1 |
| Sin City | comic books series by Frank Miller | 1 |
| Sin City: A Dame to Kill For | 2014 film | 1 |
| Sing "Yesterday" for Me | Japanese manga series | 1 |
| Sing "Yesterday" for Me | Japanese anime television series | 1 |
| Sins of Commission | Book by Susan Wright, from 1994 | 7 |
| Sirach | one of Deuterocanonical books | 3 |
| Sir Christèmas | song composed by anonymous with lyrics by anonymous | 1 |
| Sir Gawain and the Green Knight | late 14th-century Middle English chivalric romance | 1 |
| Six Feet Under | American drama television series | 3 |
| Six of Crows | 2015 novel by Leigh Bardugo | 2 |
| Skagboys | book by Irvine Welsh | 3 |
| Sket Dance | Japanese manga series | 1 |
| Sket Dance | Japanese anime television series | 1 |
| Skinner & the Superintendent | segment of The Simpsons: 22 Short Films About Springfield | 2 |
| Skins | British television series | 12 |