| Work | Description | Characters |
|---|---|---|
| She's Having a Baby | 1988 film by John Hughes | 1 |
| She Wronged Him Right | 1934 film by Dave Fleischer | 1 |
| Shiki | 2019 video game | 1 |
| Shiki | Japanese anime television series | 1 |
| Shimoneta | Japanese anime television series | 1 |
| Shimoneta: A Boring World Where the Concept of Dirty Jokes Doesn't Exist | Japanese light novel, manga, and anime series | 4 |
| Shindig | episode of Firefly (S1 E4) | 1 |
| Shin Megami Tensei: Nocturne | 2003 role-playing video game developed by Atlus | 1 |
| Shirobako | Japanese anime television series | 1 |
| Shirobako: The Movie | 2020 Japanese animated film by Tsutomu Mizushima | 1 |
| Shockwave | Star Trek: Enterprise novel | 3 |
| Shōgun | 1975 novel by James Clavell | 1 |
| Shoot the Bullet | video game | 2 |
| Shōwa Genroku Rakugo Shinjū | Japanese manga series | 1 |
| Showcase | title of several comic anthology series published by DC Comics | 2 |
| Shredder's New Sword | episode of the 1987–1996 Teenage Mutant Ninja Turtles animated television series | 2 |
| Shrek | 2001 animated comedy | 4 |
| Shrek 2 | 2004 film directed by Andrew Adamson, Kelly Asbury and Conrad Vernon | 5 |
| Shrek 2 | video game | 3 |
| Shrek 2: Team Action | 2004 video game | 3 |
| Shrek 4-D | 2003 4D film at various theme parks around the world | 2 |
| Shrek 5 | 2019 film directed by Andrew Adamson | 1 |
| Shrek Forever After | 2010 film directed by Mike Mitchell | 4 |
| Shrek Forever After | 2010 video game | 1 |
| Shrek: Hassle at the Castle | 2002 video game | 1 |
| Shrek Smash n' Crash Racing | 2006 video game | 1 |
| Shrek Super Party | 2002 video game | 1 |
| Shrek SuperSlam | 2005 video game | 5 |
| Shrek the Halls | 2007 television special directed by Gary Trousdale | 3 |
| Shrek the Third | 2007 film directed by Chris Miller | 5 |
| Shrek the Third | 2007 video game | 3 |
| Shrek universe | franchise | 1 |
| Shuggie Bain | 2020 novel by Douglas Stuart | 3 |
| Shugo Chara! | Japanese manga series | 1 |
| Shugo Chara! | Japanese anime television series | 1 |
| Siddhartha | novel by Hermann Hesse | 1 |
| Silas Marner | novel by George Eliot | 1 |
| Silent Hill | video game series | 2 |
| Silent Hill 2 | 2001 survival horror video game developed by Konami | 1 |
| Silicon Avatar | episode of Star Trek: The Next Generation (S5 E4) | 5 |
| Silicon Valley | 2014–2019 American television series | 3 |
| Silver Spoon | Japanese anime television series | 1 |
| Silver Spoon | Japanese manga series | 1 |
| Silver Surfer | comic book | 1 |
| Simpsons Comics | comic book series | 1 |
| Simpsorama | episode of The Simpsons (S26 E6) | 1 |
| Sin City | 2005 American crime thriller film written, produced and directed by Frank Miller and Robert Rodriguez | 1 |
| Sin City | comic books series by Frank Miller | 1 |
| Sin City: A Dame to Kill For | 2014 film | 1 |
| Sing "Yesterday" for Me | Japanese anime television series | 1 |
| Sing "Yesterday" for Me | Japanese manga series | 1 |
| Sins of Commission | Book by Susan Wright, from 1994 | 7 |
| Sirach | one of Deuterocanonical books | 3 |
| Sir Christèmas | song composed by anonymous with lyrics by anonymous | 1 |
| Sir Gawain and the Green Knight | late 14th-century Middle English chivalric romance | 1 |
| Six Feet Under | American drama television series | 3 |
| Six of Crows | 2015 novel by Leigh Bardugo | 2 |
| Skagboys | book by Irvine Welsh | 3 |
| Sket Dance | Japanese anime television series | 1 |
| Sket Dance | Japanese manga series | 1 |
| Skinner & the Superintendent | segment of The Simpsons: 22 Short Films About Springfield | 2 |
| Skins | British television series | 12 |
| Skyfall | 2012 James Bond film by Sam Mendes | 1 |
| Slam Dunk | Japanese manga series | 1 |
| Slayers | Japanese media franchise | 1 |
| Sleeping Beauty | 1959 American animated musical fantasy film produced by Walt Disney | 2 |
| Slippin' Jimmy | American animated comedy television series | 1 |
| Small Moral Works | work by Giacomo Leopardi | 1 |
| Smallville | American television series | 13 |
| Smallville (season 11) | 1 | |
| Smiley's People | book | 1 |
| Smiling Friends | Australian-American adult animated television series | 2 |
| Snowpiercer | American dystopian thriller television series | 2 |
| Snow White | 1933 film directed by Dave Fleischer | 1 |
| Snow White and the Seven Dwarfs | 1937 American animated film | 4 |
| So Does an Automobile | 1939 film by Dave Fleischer | 1 |
| Sofia the First | American animated television series | 1 |
| Solo: A Star Wars Story | 2018 American epic space opera film in the Star Wars franchise directed by Ron Howard | 4 |
| Solomon | oratorio by Georg Friedrich Händel | 1 |
| Solomon and Sheba | 1959 film | 1 |
| Solomon & Sheba | 1995 film by Robert M. Young | 1 |
| Something ends, Something begins | short story by Andrzej Sapkowski | 1 |
| Something Greater | short story by Andrzej Sapkowski | 1 |
| Song of Songs | book of the Bible | 1 |
| Sonic Advance | 2001 platform video game | 1 |
| Sonic Advance 2 | 2002 platform video game | 5 |
| Sonic Advance 3 | 2004 platform video game | 1 |
| Sonic Adventure | 1998 3D platforming video game developed by Sonic Team | 1 |
| Sonic Adventure 2 | 2001 platform video game | 3 |
| Sonic Adventure 2: Battle | 2002 video game | 1 |
| Sonic & All-Stars Racing Transformed | 2012 video game | 1 |
| Sonic and the Black Knight | 2009 platform video game | 1 |
| Sonic and the Secret Rings | 2007 platform video game | 1 |
| Sonic Battle | video game | 6 |
| Sonic Chronicles: The Dark Brotherhood | video game | 1 |
| Sonic Forces | 2017 video game | 9 |
| Sonic Free Riders | 2010 video game | 1 |
| Sonic Frontiers | 2022 platform video game developed by Sonic Team | 1 |
| Sonic Heroes | 2003 video game | 7 |
| Sonic & Knuckles | 1994 platform video game | 1 |