| Work | Description | Characters |
|---|---|---|
| Saints Row 2 | 2008 open world action-adventure video game developed by Volition, Inc | 1 |
| Saints Row: Gat out of Hell | video game | 1 |
| Saints Row IV | 2013 open world action-adventure video game | 1 |
| Saints Row: The Third | 2011 video game | 1 |
| Sally Swing | 1938 film by Dave Fleischer | 1 |
| Saludos Amigos | 1942 US animated film | 1 |
| Samurai Champloo | Japanese anime television series | 1 |
| Samurai Flamenco | Japanese anime television series | 1 |
| Samurai Jack | American animated television series | 2 |
| Samurai Jack: The Amulet of Time | 2003 video game | 1 |
| Samurai Jack: The Shadow of Aku | 2004 video game | 2 |
| Sanctuary | science fiction-fantasy TV series from Canada | 2 |
| Sanctuary | Book by John Vornholt, from 1992 | 5 |
| Sandworms of Dune | novel by Kevin J. Anderson | 2 |
| San Paolo | 2000 television film directed by Roger Young | 1 |
| Santa Claus Conquers the Martians | 1964 film by Nicholas Webster | 1 |
| Saratoga | Star Trek novel by Michael Jan Friedman | 6 |
| Sarek | novel by Ann C. Crispin | 2 |
| Saved by the Bell | American television sitcom (1989-1993) | 1 |
| Saved by the Bell: Hawaiian Style | 1992 television film directed by Don Barnhart | 1 |
| Saved by the Bell: The College Years | American television series | 1 |
| Saved by the Bell: The New Class | American sitcom television series | 1 |
| Saved by the Bell: Wedding in Las Vegas | 1994 television film directed by Jeff Melman | 1 |
| Saw | film series | 1 |
| Say Anything... | 1989 American teen romantic comedy-drama film | 2 |
| Sayonara, Zetsubou-Sensei | Japanese manga series | 1 |
| Scandal | 2012 American political thriller television series | 1 |
| Scandal, season 7 | season of television series | 1 |
| Scared Shrekless | 2010 film directed by Gary Trousdale | 3 |
| Scarface | 1983 crime drama film directed by Brian De Palma | 1 |
| Scarface: The World Is Yours | 2006 video game | 1 |
| Scarlett | 1991 novel by Alexandra Ripley | 1 |
| Scarlet Weather Rhapsody | 2008 video game | 3 |
| Schitt's Creek | Canadian television sitcom | 7 |
| School Days | Japanese eroge visual novel | 3 |
| School Days | Japanese anime television series | 3 |
| School-Live! | Japanese manga series | 1 |
| School-Live! | Japanese anime television series | 1 |
| School of Rock | musical | 1 |
| School Rumble | Japanese manga series | 1 |
| Scoob! | 2020 film directed by Tony Cervone | 5 |
| Scooby-Doo | American animated cartoon franchise | 3 |
| Scooby-Doo | 2002 comedy mystery adventure film directed by Raja Gosnell | 6 |
| Scooby-Doo 2: Monsters Unleashed | 2004 video game | 1 |
| Scooby-Doo 2: Monsters Unleashed | 2004 film by Raja Gosnell | 5 |
| Scooby-Doo! & Batman: The Brave and the Bold | 2018 film | 1 |
| Scooby-Doo! Curse of the Lake Monster | 2010 television film directed by Brian Levant | 5 |
| Scooby-Doo! The Mystery Begins | 2009 television film directed by Brian Levant | 5 |
| Scooby-Doo, Where Are You! | television series | 2 |
| scoop | film by Woody Allen in 2006 | 1 |
| Scorpion | two-part episode of Star Trek: Voyager | 1 |
| Scott Pilgrim | Canadian graphic novels | 2 |
| Scott Pilgrim Takes Off | 2023 action adventure romantic comedy animated series | 1 |
| Scott Pilgrim vs. the World | 2010 American-British-Japanese-Canadian film by Edgar Wright | 2 |
| Scott Pilgrim vs. the World: The Game | 2010 video game | 1 |
| Scream 3 | 2000 American slasher film | 1 |
| Scream Queens | 2015 TV series | 1 |
| Scrubs | American medical comedy-drama television series | 2 |
| Sea of Thieves | 2018 video game developed by Rare | 1 |
| Season of Storms | novel by Andrzej Sapkowski | 2 |
| Second Contact | episode of Star Trek: Lower Decks | 7 |
| Second Epistle of Peter | book of the Bible | 1 |
| Second Epistle to Timothy | book of the Bible | 1 |
| Secretary | 2002 film by Steven Shainberg | 1 |
| Secretary: Part 4 | 497th strip of the webcomic xkcd | 1 |
| Secretary: Part 5 | 498th strip of the webcomic xkcd | 1 |
| Sega Superstars | 2004 video game | 1 |
| Seinfeld | American sitcom | 5 |
| Seize the Fire | Book by Michael A. Martin | 2 |
| Sekai-ichi Hatsukoi | Japanese manga series | 1 |
| Sekiro: Shadows Die Twice | 2019 action-adventure video game developed by FromSoftware | 1 |
| Selector Infected WIXOSS | Japanese anime television series | 1 |
| Serenity | episode of Firefly (S1 E1) | 1 |
| Serenity | novelization of the 2005 movie | 2 |
| Serenity | 2005 space western film directed by Joss Whedon | 3 |
| Serenity: Better Days | comic book miniseries | 2 |
| Serenity Role Playing Game | tabletop role-playing game based on Serenity and Firefly | 1 |
| Serenity: Those Left Behind | comic book | 2 |
| Serial Experiments Lain | 1998 television anime series | 2 |
| Service with a Smile | 1937 film by Dave Fleischer | 1 |
| Sesame Street | American children's television program | 3 |
| Seven of Nine | Book by Christie Golden, from 1998 | 6 |
| Seventeen Moments of Spring | 1973 Soviet twelve-part television miniseries | 1 |
| Severance | American television series (2022–) | 8 |
| Severus Snape and the Marauders | 2016 short film by Justin Zagri | 7 |
| Sex and the City | American TV series | 5 |
| Sex Education | UK/US 2019 Netflix TV Series | 2 |
| Shadow | Star Trek: Section 31 novel | 6 |
| Shadow and Bone | 2021 American fantasy television series | 3 |
| Shadow and Bone | 2012 novel by Leigh Bardugo | 1 |
| Shadow Lord | book by Laurence Yep | 4 |
| Shadow of the Giant | 2005 Book by Orson Scott Card | 1 |
| Shadows On The Sun | Book by Michael Jan Friedman, from 1993 | 5 |
| Shadow the Hedgehog | 2005 video game | 7 |
| Shahnameh | long epic Persian poem written by Ferdowsi | 1 |
| Shakaar | episode of Star Trek: Deep Space Nine (S3 E24) | 1 |
| Shaman King | Japanese manga series | 4 |
| Shaman King | 2021 Japanese anime television series | 4 |
| Shaman King | 2001 Japanese anime television series | 4 |
| Shameless | American television comedy-drama series | 4 |